(1R,2S,3S)-Aprepitant Chemical Properties

Density 

1.51±0.1 g/cm3(Predicted)

pka

8.06±0.20(Predicted)

(1R,2S,3S)-Aprepitant Usage And Synthesis

Uses

(2S,3S,1’R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. (2S,3S,1’R)-Aprepitant is also a useful synthetic intermediate in the synthesis of morpholine tachykinin receptor antagonist prodrugs.

(1R,2S,3S)-Aprepitant(172822-28-5)Related Product Information

• Aprepitant
• 5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
• (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
• Benzyl dihydrogen phosphate
• (2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
• Aprepitant Impurity 19
• [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
• Fosaprepitant Impurity 6
• Aprepitant
• ent-Aprepitant
• (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
• Aprepitant
• 1,1,1-Trimethoxy-2-chloroethane
• Aprepitant
• Defluoro Aprepitant
• Aprepitant Impurity B HCl
• Aprepitant Impurity 11 HCl
• Aprepitant Impurity 2