DBCO-NHS Ester
DBCO-NHS Ester Basic information
- Product Name:
- DBCO-NHS Ester
- Synonyms:
-
- DBCO-NHS
- N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate
- DBCO-NHS ester (DBCO NHS ester)
- 11,12-Didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid 2,5-dioxo-1-pyrrolidinyl ester
- CAS_1353016-71-3
- Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
- 4-[(5-aza-3，4:7，8-dibenzocyclooctan-1-yne)-5-yl]-4-oxobutyrate-n-succinimide
- Dibenz[b,?f]azocine-5(6H)-butanoic acid,11,12-didehydro-γ-oxo-,2,5-dioxo-1-pyrrolidinyl ester （DBCO-NHS）
- CAS:
- 1353016-71-3
- MF:
- C23H18N2O5
- MW:
- 402.4
- Product Categories:
-
- ADC LINKER
- Mol File:
- 1353016-71-3.mol
DBCO-NHS Ester Chemical Properties
- Boiling point:
- 670.2±65.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- -0.23±0.20(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Moisture Sensitive
DBCO-NHS Ester Usage And Synthesis
Description
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging.
Uses
DBCO NHS ester contains an NHS carbonate group and a DBCO group. The spacer contains a photocleavable nitrobenzyloxyl group, which can be efficiently cleaved under UV to release the conjugated molecules. DBCO on the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
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