BMPO Chemical Properties

Melting point:

90-91 °C

Boiling point:

339.8±35.0 °C(Predicted)

Density 

1.06±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 10 mg/ml

form 

A crystalline solid

pka

1.74±0.40(Predicted)

color 

Off-white to light yellow

InChI

InChI=1S/C10H17NO3/c1-9(2,3)14-8(12)10(4)6-5-7-11(10)13/h7H,5-6H2,1-4H3

InChIKey

MDMUYJRRYYXDLZ-UHFFFAOYSA-N

SMILES

[N+]1([O-])=CCCC1(C)C(OC(C)(C)C)=O

BMPO Usage And Synthesis

Uses

BMPO (BocMPO) is a cell-permeable superior spin trap with favorable chemical and spectroscopic features. BMPO (BocMPO) can be used for detecting thiyl radicals, hydroxyl radicals, superoxide anions and glutathiyl radicals[1].

References

[1] H Zhao, et al. Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals. Free Radic Biol Med DOI:10.1016/s0891-5849(01)00619-0
[2] Hongtao Zhao, et al. Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Proc Natl Acad Sci U S A DOI:10.1073/pnas.0501719102
[3] Nadeem Khan, et al. Spin traps: in vitro toxicity and stability of radical adducts. Free Radic Biol Med. 2003 Jun 1;34(11):1473-81. DOI:10.1016/s0891-5849(03)00182-5

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