ML364 Chemical Properties

Density 

1.457±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 20 mg/ml

form 

A crystalline solid

pka

6.51±0.50(Predicted)

color 

Light yellow to yellow

ML364 Usage And Synthesis

Uses

ML364 is a small molecular inhibitor of the deubiquitinase USP2, which accelerates cyclin D1 degrdation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma.

Biological Activity

ML364 is a potent and specific inhibitor of the deubiquitinase USP2 th at induces cellular Cyclin D1 degradation in HCT116 colorectal cancer cells, followed by cell cycle arrest and apoptosis. Also, ML364 inhibits homologous recombination (HR)-mediated DNA repair.

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