Trofinetide
Trofinetide Basic information
- Product Name:
- Trofinetide
- Synonyms:
-
- Trofinetide(NNZ2566)
- TROFINETIDE; NNZ2566 ;NNZ 2566; NNZ-2566
- NNZ-2566
- L-Glutamic acid, glycyl-2-methyl-L-prolyl-
- Trofinetide
- Trofinetide,NNZ 2566,NNZ2566,Inhibitor,inhibit
- Glutamic acid, glycyl-
- prolyl-
- CAS:
- 853400-76-7
- MF:
- C13H21N3O6
- MW:
- 315.32
- Product Categories:
-
- API
- Mol File:
- 853400-76-7.mol
Trofinetide Chemical Properties
- Melting point:
- 144 °C
- Boiling point:
- 655.4±55.0 °C(Predicted)
- Density
- 1.377±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 3.51±0.10(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C13H21N3O6/c1-13(5-2-6-16(13)9(17)7-14)12(22)15-8(11(20)21)3-4-10(18)19/h8H,2-7,14H2,1H3,(H,15,22)(H,18,19)(H,20,21)/t8-,13-/m0/s1
- InChIKey
- BUSXWGRAOZQTEY-SDBXPKJASA-N
- SMILES
- C(O)(=O)[C@H](CCC(O)=O)NC(=O)[C@]1(C)CCCN1C(=O)CN
Trofinetide Usage And Synthesis
Uses
Trofinetide is a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), that has shown to be neuroprotective in animal models of brain injury.
in vivo
Trofinetide (NNZ-2566) suppresses penetrating ballistic-like brain injury (PBBI) induced inflammatory cell infiltration at 3 days following PBBI as compare to vehicle treatment. Trofinetide treatment significantly reduces the elevation of IL-6 (79%), E-selectin (81%), IL-1β (76%) and TNF-α (72%) mRNA levels in the injured hemisphere at 12 h post-PBBI, with maximal inhibition occurring between 12 h and 24 h. Trofinetide treatment does not affect the PBBI-induced up-regulation of IL-6 expression at any time point, but does produce significant reductions in the injury-induced up-regulation of IL-1β, INF-γ, and TNF-α expression. Trofinetide treatment suppresses IL-1β expression in the injured brain hemisphere for up to 7 days post-PBBI[1]. The high doses of Trofinetide (NNZ-2566) (10 and 100 mg/kg bolus followed by continuous infusion) attenuate non-convulsive seizure (NCS) occurring beyond 2 h after permanent middle cerebral artery occlusion (pMCAo). All doses of Trofinetide completely suppress the delayed occurrence of NCS as compare with the vehicle-treated animals[2].
TrofinetideSupplier
- Tel
- 0838-2809458 13350585791
- pharm@biots.cn
- Tel
- 0086-13852538605 13308012069
- 13308012069@189.cn
- Tel
- 13921770081
- svp01@magicbiotech.cn
- Tel
- 19353112242
- 1816280386@qq.com
- Tel
- 15397062932
- sales1@gotopbio.com