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Eprinomectin

Basic information Safety Supplier Related

Eprinomectin Basic information

Product Name:
Eprinomectin
Synonyms:
  • EPRINOMECTIN
  • (4''R)-4''-(ACETYLAMINO)-4''-DEOXY-AVERMECTIN B1
  • Emamectin B1 Benzoate
  • EPRINOMECTIN VETRANAL
  • EprinomectinB1
  • Avermectin B1, 4-(acetylamino)-4-deoxy-, (4R)-
  • (4''r)-4''-(acetylamino)-4''-deoxy-avermectin b1solution
  • eprinex
CAS:
123997-26-2
MF:
C50H75NO14
MW:
914.1288
EINECS:
602-966-4
Product Categories:
  • Chiral Reagents
  • Heterocycles
Mol File:
123997-26-2.mol
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Eprinomectin Chemical Properties

Melting point:
163-166°C
Density 
1.23
Flash point:
2 °C
storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
Stability:
Hygroscopic
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Safety Information

Hazard Codes 
F,Xn,N,T
Risk Statements 
11-20/21/22-36-62-50/53-25-63
Safety Statements 
26-36/37-16-61-60-45
RIDADR 
UN 2811
WGK Germany 
3
HS Code 
2941906000
Toxicity
LD50 orally in mice: 24 mg/kg (Jones)

MSDS

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Eprinomectin Usage And Synthesis

Description

Eprinomectin is a semisynthetic avermectin that consists of a mixture of two homologues, eprinomectin B1a (4 epi-acetylamino-4 -deoxy-avermectin B1; 90%) and eprinomectin B1b (10%).Eprinomectin was developed as a topical endectocide for all categories of cattle including lactating dairy cattle, and the process by which eprinomectin was selected for further development has been described (90). Briefly, several hundred avermectin/ milbemycin analogues were screened in a sheep model for efficacy against a range of endoparasites and in lactating dairy cows for a low milk:plasma partitioning ratio. Themilk:plasma ratio for eprinomectin is <0.2; ivermectin, by comparison, partitions equally between milk and plasma.

Description

Eprinomectin is an avermectin with anthelmintic and insecticidal activities. It is comprised of eprinomectin B1a and eprinomectin B1b . Eprinomectin (≥0.08 mg/kg, applied topically) reduces worm burden by 99% or more in bovine models of adult H. placei, O. ostertagi, T. axei, Cooperia punctata, N. helvetianus, O. radiatum, or D. viviparus infection. It also reduces parasite burden in bovine models of horn fly (H. irritans) or mange mite (C. bovis) infestation, as well as in cows naturally infested with lice (L. vituli), when applied topically at doses ranging from 0.16 to 0.5 mg/kg. Formulations containing eprinomectin have been used in the treatment and control of a variety of endo- and ectoparasites in cattle.

Chemical Properties

Crystalline Solid

Uses

A mixture of semi-synthetic Avermectins; containing 90% or more of component B1a and 10% or less of component B1b. Antiparasitic

Uses

Eprinomectin is a mixture of eprinomectins B1a and B1b in a 9:1 ratio, produced from a mixture of avermectin B1a and B1b. Eprinomectin is used commercially as a topical endectocide (insecticide, miticide and nematocide) for cattle, including lactating dairy cows. Like all avermectins and milbemycins, eprinomectin acts by binding to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite, mite or insect.

Uses

A mixture of Eprinomectin B1a and B1b showing anti-anthelintic activity

brand name

Eprinex [Veterinary](Merial).

Veterinary Drugs and Treatments

In cattle, eprinomectin is indicated for a variety gastrointestinal roundworms including adult and L4 stages of Haemonchus placei, Ostertagia ostertagi, Trichostrongylus axei and colubriformis, Cooperia oncophora/punctata/surnabada, Nematodirus helvetianus, Oesophagostomum radiatum, Bunostomum phlebotomum, and Trichuris spp. (adults only); cattle grubs; lice; mange mites; horn flies (for 7 days after treatment), and lungworms (Dictyocaulus vivaparus—for 21 days after treatment).
Topical eprinomectin may be useful for the topical treatment of ear mites (Psoroptes cuniculi) in rabbits. One small study (6 subjects) showed partial response when rabbits were dosed at 5 mg/kg topically, twice at 14 day intervals. (Ulutas, Voyvoda et al. 2005)

Toxicity evaluation

Acute oral LD50 for rats: 55mg/kg

EprinomectinSupplier

Wuhan Dingxintong Pharmaceutical Co. , Ltd. Gold
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027-027-83984790 17720532645
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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LGM Pharma
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1-(800)-881-8210
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Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
Hunan Hui Bai Shi Biotechnology Co., Ltd.
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0731-85526065 13308475853
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ivy@hnhbsj.com