6-Fluoronicotinic acid Chemical Properties

Melting point:

144-148 °C(lit.)

Boiling point:

309.4±22.0 °C(Predicted)

Density 

1.419±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

3.41±0.10(Predicted)

color 

White to Orange to Green

InChI

InChI=1S/C6H4FNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H,9,10)

InChIKey

UJDLCTNVHJEBDG-UHFFFAOYSA-N

SMILES

C1=NC(F)=CC=C1C(O)=O

CAS DataBase Reference

403-45-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich

6-Fluoronicotinic acid Usage And Synthesis

Chemical Properties

White to Orange to Green powder to crystal.

Uses

6-Fluoronicotinic acid is a fluorinated nicotinic acid that is a derivative of pyridine, with a carboxylic acid at 3-position and a fluorine at 6-position. It is used as a pharmaceutical intermediate and a molecular scaffold to synthesize tracers for positron emission tomography, for visualizing and measuring changes in metabolic processes.

References

[1] LATIFA RBAH-VIDAL. Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [¹⁰F]ICF01006, a highly promising melanoma PET tracer.[J]. European Journal of Nuclear Medicine and Molecular Imaging, 2012, 39 9: 1449-1461. DOI:10.1007/s00259-012-2168-y.
[2] FALGUNI BASULI. Fast indirect fluorine-18 labeling of protein/peptide using the useful 6-fluoronicotinic acid-2,3,5,6-tetrafluorophenyl prosthetic group: A method comparable to direct fluorination.[J]. Journal of labelled compounds & radiopharmaceuticals, 2017, 60 3 1: 168-175. DOI:10.1002/jlcr.3487.
[3] G. F. HAWKINS ARTHUR R. THE PREPARATION OF 5-FLUORONICOTINIC ACID AND 5-FLUORONICOTINAMIDE1[J]. The Journal of Organic Chemistry, 1949, 14 2: 328-332. DOI:10.1021/jo01154a021.
[4] Lal, Achchhe, and Devendra Kumar Singh. "Theoretical and Experimental Studies of Vibrational Spectra of 6-fluoronicotinc Acid."

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