WAY-151932
WAY-151932 Basic information
- Product Name:
- WAY-151932
- Synonyms:
-
- WAY-151932
- VNA-932
- Methanone, [2-chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl-
- WAY-VNA 932
- WAY151932,WAY 151932
- CAS:
- 220460-92-4
- MF:
- C23H19ClN4O
- MW:
- 402.88
- Mol File:
- 220460-92-4.mol
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WAY-151932 Chemical Properties
- Boiling point:
- 630.6±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 0.04±0.12(Predicted)
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WAY-151932 Usage And Synthesis
Biological Activity
WAY-151932 is an antidiuretic hormone V2 receptor agonist with IC50 of 80.3 and 778 nM in human V2 and V1a binding assays, respectively.
in vitro
WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV 2 receptors in a dose-dependent manner with an EC 50 of 0.74±0.07 nM.
in vivo
Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED 50 =0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile.
target
IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)
WAY-151932Supplier
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