PROPOXYPHENE HYDROCHLORIDE Chemical Properties

Melting point:

165-1670C

alpha 

D25 +59.8° (c = 0.6 in water)

Flash point:

11 °C

storage temp. 

-20°C Freezer

solubility 

Very soluble in water, freely soluble in ethanol (96 per cent).

Water Solubility 

3.7mg/L(25 ºC)

CAS DataBase Reference

1639-60-7(CAS DataBase Reference)

EPA Substance Registry System

Propoxyphene hydrochloride (1639-60-7)

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

16-36/37-45

RIDADR 

3249

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

LD50 in mice, rats (mg/kg): 28, 15 i.v.; 111, 58 i.p.; 211, 134 s.c.; 282, 230 orally (Emerson)

PROPOXYPHENE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White Solid

Uses

Dextropropoxyphene is a controlled substance (narcotic)

Uses

Dextropropoxyphene is a controlled substance (opiate). Analgesic (narcotic). The α-dl-and d-diastereoisomers possess marked analgesic activity in contrast to the β-diastereoisomers which are substantially inactive.

brand name

Darvon (Xanodyne); Dolene (Clonmel).

Safety Profile

A human poison by ingestion. An experimental poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Human systemic effects by ingestion: anorexia, ataxia, chronic pulmonary edema, cyanosis, increased body temperature, jaundice, nausea or vomiting, sleep disturbance. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also PROPOXYPHENE.

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