Ald-Ph-PEG2-amine Chemical Properties

Boiling point:

507.8±45.0 °C(Predicted)

Density 

1.166±0.06 g/cm3(Predicted)

pka

13.53±0.46(Predicted)

Ald-Ph-PEG2-amine Usage And Synthesis

Description

Ald-Ph-PEG2-amine TFA salt is a small molecule PEG linker with a benzaldehyde moiety and a terminal amine NH2 group. The benzaldehyde can undergo reactions with primary amine groups. The primary amine can react with carboxylic acids, activated NHS esters and other carbonyl compounds. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous solutions.

Uses

Ald-Ph-amido-C2-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Ald-Ph-PEG2-amine(2055013-56-2)Related Product Information

• Ald--Ph-PEG3-amine
• Ald-Ph-PEG4-t-butyl ester
• Acid-PEG4-t-butyl ester
• Ald--Ph-PEG2-acid
• Ald-Ph-PEG4-acid
• Ald-Ph-PEG2-t-butyl ester
• Ald-PEG4-t-butyl ester
• Acid-PEG3-t-butyl ester
• Acid-PEG6-t-butyl ester
• Ald-PEG5-t-butyl ester
• Acid-PEG5-t-butyl ester
• m-PEG4-benzaldehyde
• Ald--Ph-PEG2-NHS
• Ald-PEG4-NHS ester
• Ald-Ph-PEG6-t-butyl ester
• Ald-Ph-PEG3-Azide
• m-PEG4-CH2-aldehyde
• Ald-PEG5-Azide