Bis-(N,N'-carboxyl-PEG4)-Cy5 Chemical Properties

solubility 

Soluble in Water, DMSO, DMF, DCM

Bis-(N,N'-carboxyl-PEG4)-Cy5 Usage And Synthesis

Description

Bis-(N,N'-carboxyl-PEG4)-Cy5 is a PEG linker containing a cyanine dye with excitation/emmission maximum 649/667 nm and a free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydophilic PEG spacer increases solubility in aqueous media.

Uses

Bis-(N,N'-carboxyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005