Aminooxy-PEG3-methyl ester Chemical Properties

Boiling point:

361.4±32.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

pka

4.21±0.70(Predicted)

Aminooxy-PEG3-methyl ester Usage And Synthesis

Description

Aminooxy-PEG3-CH2CO2tBu consist of an aminooxy group and a t-butyl ester group. Aminooxy(ONH2) group can be used in bioconjugation. It is reactive with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The t-butyl protected carboxyl group can be hydrolyzed to form a free acid. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

Aminooxy-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005