Cyprodinil Chemical Properties

Melting point:

75.9°

Boiling point:

406.0±48.0 °C(Predicted)

Density 

1.21 g/cm3

vapor pressure 

5.1 x l0^-4 Pa (25 °C)

storage temp. 

0-6°C

solubility 

Chloroform: Slightly Soluble

pka

4.44 (base)

Water Solubility 

20 mg l^-1 (pH 5), 13 mg l^-1 (pH 7), 15 mg l^-1 (pH 9) 25 °C

form 

Solid

color 

White to off-white

BRN 

7813601

LogP

4.000

EPA Substance Registry System

Cyprodinil (121552-61-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38-43

Safety Statements 

26-36

RIDADR 

UN 3077

WGK Germany 

2

Hazardous Substances Data

121552-61-2(Hazardous Substances Data)

Toxicity

LD50 orally or dermally in rats: >2000 mg/kg (Heye)

MSDS

• Language:English Provider:4-Cyclopropyl-6-methyl-N-phenyl-2-pyrimidinamine

Cyprodinil Usage And Synthesis

Chemical Properties

White to Off-White Solid

Chemical Properties

White crystalline solid or beige powder

Uses

Cyprodinil is a broad-spectrum fungicide of the class of pyrimidinamines. It is commonly used for protection of cereal crops and fruits against fungal infections.

Uses

Cyprodinil is a systemic fungicide which controls a wide range of fungal diseases in cereals, grapes, pome fruits, stone fruits, berries, vegetables, field crops and ornamentals caused by Septoria, Botrytis, Monilinia, Rhynchosporium, etc.

Uses

Agricultural fungicide.

Definition

ChEBI: A member of the class of aminopyrimidine that is N-phenylpyrimidin-2-amine carrying additional cyclopropyl and methyl substituents at positions 4 and 6 respectively. A broad spectrum fungicide used to control a range of pathogens includi g Tapesia yallundae, Botrytis spp., Alternaria spp. and Rhynchospium secalis. Whilst it is a recognised irritant no serious human health concerns have been identified. It is moderately toxic to birds as w ll as most aquatic organisms and earthworms, but it is not considered toxic to honeybees.

Agricultural Uses

Fungicide: Cyprodinil is applied to the foliage of almonds, grapes, stone fruit crops, and pome fruit crops to control plant diseases. Target fungi for cyprodinil include scab and brown rot blossom

Trade name

CGA 219417® technical; CHORUS®; SWITCH®; UNIX®; VANGUARD®

Potential Exposure

Cyprodinil is an anilino pyrimidine fungicide applied to the foliage of almonds, grapes, stone fruit crops, and pome fruit crops to control plant diseases. Target fungi for cyprodinil include scab and brown rot blossom

Metabolic pathway

After single oral administration of 14C-cyprodinil to rats, cyprodinil is rapidly eliminated principally in the urine. The pattern of the metabolic profile in the urine exhibits a significant sex-related difference with respect to the major metabolite. Males and females both produce N-4- (hydroxyphenyl)-4-cyclopropyl-5-hydroxy-6- methylpyrimidin-2-yl-amine. Female rats conjugate this dihydroxy metabolite with sulfate exclusively at the 5- hydroxypyrimidinyl moiety, while males form equal amounts of the monosulfate and disulfate conjugates. Ten cultures of 12 collected microorganisms produce a monohydroxylated metabolite and the filamentous fungus, Beauveria bassiana ATCC 7159, produces a methoxylated glycoside of the monohydroxylated metabolite. Dihydroxylated metabolites and a molecular cleavage product, 4-cyclopropyl-6-methyl-2- pyrimidinylamine, are detected in certain cultures.

Shipping

UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz- ardous material, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Degradation

Cyprodinil (1) is stable to hydrolytic degradation in pH 5-9 buffer solutions at 25 °C with a DT₅₀ >1 year. Cyprodinil degrades rapidly in water when exposed to UV light (DT₅₀ ca. 14 days) (PM).

Incompatibilities

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions) if breathing has stopped, and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Do not induce vomiting when formulations containing petroleum solvents are ingested.

Waste Disposal

Recycle any unused portion of the material for its approved use or return it to the manu- facturer or supplier. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

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