3,5-Difluoroaniline Chemical Properties

Melting point:

37-41 °C (lit.)

Boiling point:

80°C 20mm

Density 

1,295 g/cm³

refractive index 

1,512-1,514

Flash point:

167 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Water Solubility 

Insoluble in water

form 

Low Melting Solid

pka

2.57±0.10(Predicted)

color 

White to yellow

BRN 

2802286

CAS DataBase Reference

372-39-4(CAS DataBase Reference)

EPA Substance Registry System

3,5-Difluoroaniline (372-39-4)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

28-36/37/39-26-36

RIDADR 

UN 1325 4.1/PG 2

WGK Germany 

3

F 

8-10-23

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214200

MSDS

• Language:English Provider:3,5-Difluorobenzenamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,5-Difluoroaniline Usage And Synthesis

Synthesis

Work on halogenated benzenes has also demonstrated the versatility of this technique and a variety of fluoro-chloro and -bromo benzenes may be de-brominated and de-chlorinated. Two patents describe removal of chlorine from 2,6-dichloro-3,5- difluoronitrobenzene giving 3,5-difluoroaniline.

Chemical Properties

white to yellowish low melting solid

Uses

3,5-Difluoroaniline has been used in the preparation of 3,5-difluorodimethylaniline.

General Description

In vitro nephrotoxic effects of 3,5-difluoroaniline has been investigated in renal cortical slices obtained from the kidneys of untreated, male Fischer 344 rats.

3,5-Difluoroaniline(372-39-4)Related Product Information

• Diphenylamine
• 4-(Trifluoromethoxy)aniline
• 4-Fluoroaniline
• N,N-Dimethylaniline
• 2-Fluoroaniline
• 3-Fluoroaniline
• Sodium diphenylamine-4-sulfonate
• 2-Aminobenzotrifluoride
• N,N-Dimethyl-1,4-phenylenediamine
• 2,4-Difluoroaniline97%
• 2,3,4,5-Tetrafluoronitrobenzene
• 3,5-Difluoronitrobenzene
• 4-AMINO-2,3,5,6-TETRAFLUOROBENZOIC ACID
• 4-AMINO-2,3,5,6-TETRAFLUOROBENZAMIDE
• 2,6-Difluoroaniline
• 2,5-Difluoroaniline
• 4,4'-Diaminooctafluorobiphenyl
• 2,3,5,6-TETRAFLUOROPHENYLHYDRAZINE