2-Chloro-N,N-dimethylacetamide Chemical Properties

Melting point:

15-16 °C

Boiling point:

98-100°C/11mm

Density 

1.182 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.479

Flash point:

98-100°C/11mm

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), Hexane (Slightly), Methanol (Slightly)

pka

-0.95±0.70(Predicted)

form 

Liquid

color 

Clear colorless to pale yellow

BRN 

969568

InChIKey

XBPPLECAZBTMMK-UHFFFAOYSA-N

CAS DataBase Reference

2675-89-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 3

WGK Germany 

3

HS Code 

29241990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Chloro-N,N-dimethylacetamide Usage And Synthesis

Uses

2-Chloro-N,N-dimethylacetamide is N,M-dialkyl amide used as an organic catalyst in the preparation of phosphorylated thiosemicarbazide.

Uses

2-Chloro-N,N-dimethylacetamide (N,N-dimethylchloroacetamide) was used in the synthesis of (S)-carbinoxamine.

Synthesis

In a 500 mL four-necked flask, sodium hydrogen carbonate 126.0 g (1.50 mol) and 146.8 g of toluene were added, and the mixture was stirred while cooling. The internal temperature was maintained below 5 ° C, 112.9 g (1.00 mol) of chloroacetyl chloride was added dropwise over 4 hours, and 49.6 g (1.10 mol) of dimethylamine gas was blown over 4 hours. After stirring at -2 to 1 ° C. for 1 hour, the reaction solution was filtrated under reduced pressure to remove inorganic salt crystals by filtration. The crystals were washed with 100 g of toluene, and the filtrate and washings were combined. After separating and removing the aqueous layer in the filtrate washings, the toluene layer was concentrated under reduced pressure to obtain 113.2 g (0.93 mol) of oily 2-chloro-N, N-dimethylacetamide. The yield was 93.1%.

2-Chloro-N,N-dimethylacetamide(2675-89-0)Related Product Information

• Chloroacetamide
• Epichlorohydrin
• 2,6-Dimethylphenol
• tert-Butyldimethylsilyl chloride
• 2,6-Lutidine
• Dichloroacetamide
• 2,2,2-Trichloroacetamide
• Chlorodimethylphenylsilane
• DIMETHYLTHEXYLSILYL CHLORIDE
• N,N-Dimethylacetamide
• Chloroacetic acid
• Difluorochloromethane
• 2-Chloro-N,N-bis(2-methylpropyl)acetamide
• FLUOROIMIDE
• 2-Chloro-N,N-diethylacetamide
• Alachlor
• ALLIDOCHLOR
• Acetamide