Pentafluoropyridine Chemical Properties

Melting point:

-42

Boiling point:

83-85 °C

Density 

1.54 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.386(lit.)

Flash point:

75 °F

storage temp. 

Inert atmosphere,2-8°C

form 

Liquid

pka

-12.08±0.28(Predicted)

color 

Clear colorless

Specific Gravity

1.62

Water Solubility 

Not miscible or difficult to mix in water.

BRN 

1427064

InChIKey

XTGOWLIKIQLYRG-UHFFFAOYSA-N

CAS DataBase Reference

700-16-3(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, pentafluoro-(700-16-3)

Safety Information

Hazard Codes 

Xn,F,Xi

Risk Statements 

10-20/21/22-36/37/38

Safety Statements 

26-28-24/25-16

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

Hazard Note 

Flammable/Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Pentafluoropyridine Usage And Synthesis

Synthesis

Historically, potassium fluoride has been used with solvents to perform the Halex reaction and Finger and Kruse established the use of polar aprotic solvents in the Halex reaction, with DMSO and DMF being used for the conversion of pentachloropyridine to pentafluoropyridine.

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Pentafluoropyridine was used in the preparation of η2-C,C coordinated pentafluoropyridine complex. It was also used in the preparation of polyfluorinated coupling products via Pd(0)-catalyzed cross-coupling reaction with diarylzinc compounds. It was also used as derivatizing reagent in the sensitive GC-MS method for determination of the four endocrine disrupting chemicals.

General Description

The reactions of pentafluoropyridine with cobalt(0) complex, Co(PMe₃)₄ was investigated.

Purification Methods

Distil it through a concentric tube column; it has in cyclohexane at 256.8nm. [Chambers et al. J Chem Soc 3573 1964, NMR: Bell et al. J Fluorine Chem 1 51 1971.] The hexafluoroantimonate has m 98-102o(dec) after crystallisation from liquid SO2. [Beilstein 20/5 V 401.]

Pentafluoropyridine(700-16-3)Related Product Information

• Penfluridol
• 4-Methylpyridine
• 2,6-Lutidine
• 2-Chloro-5-chloromethylpyridine
• Chromium picolinate
• Sulfasalazine
• Flupirtine
• Pyridine hydrofluoride
• PENTAFLUOROPROPIONALDEHYDE HYDRATE
• IODOPENTAFLUOROBENZENE
• PENTAFLUOROPHENOXYACETIC ACID
• ETHYL PENTAFLUOROPROPIONYLACETATE
• Perfluoropropionic anhydride
• PENTAFLUOROPHENYLHYDRAZINE
• Perfluoropropionic acid
• Pentafluorobenzaldehyde
• PENTAFLUOROTHIOPHENOL
• 2,3-Difluoropyridine