ETHYL TETRAHYDROPYRAN-4-YL-ACETATE Chemical Properties

Boiling point:

73-75 0,2mm

Density 

1.0268 g/cm3(Temp: 13.4 °C)

refractive index 

1.4572 (13.4℃)

storage temp. 

Inert atmosphere,Room Temperature

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

103260-44-2

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-36/37/39-23

Hazard Note 

Irritant

HS Code 

2932990090

ETHYL TETRAHYDROPYRAN-4-YL-ACETATE Usage And Synthesis

Synthesis

General procedure for the synthesis of ethyl tetrahydropyran-4-yl-acetate from ethyl 2-(dihydro-2H-pyran-4(3H)-ylidene)acetate: ethyl tetrahydro-4H-pyran-4-ylidene acetate (16.0 g, 94 mmol) was reacted with Pd/NH4COOH at 80 °C to give the colorless oily product ethyl tetrahydropyran-4-yl-acetate. Yield: 16.3 g (quantitative), mass spectral (MS) data: m/z 173.2 ([M + H]+).

References

[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 25, p. 6255 - 6269
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 23, p. 6309 - 6323
[3] Patent: US6340691, 2002, B1. Location in patent: Page column 66
[4] Patent: EP1147080, 2004, B1. Location in patent: Page 49
[5] Patent: WO2013/37960, 2013, A1. Location in patent: Page/Page column 76

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