Olmesartan Chemical Properties

Melting point:

186-188°C

Boiling point:

738.3±70.0 °C(Predicted)

Density 

1.33

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

pka

2.39±0.50(Predicted)

form 

powder

color 

white to beige

Stability:

Hygroscopic

CAS DataBase Reference

144689-24-7(CAS DataBase Reference)

Safety Information

RTECS 

NI4014100

HS Code 

29339900

Hazardous Substances Data

144689-24-7(Hazardous Substances Data)

Olmesartan Usage And Synthesis

Chemical Properties

White Solid

Uses

An labelled angiotensin II receptor antagonist. Used as an anti-hypertensive

Uses

Angiotensin II inhibitor, antihypertensive

Uses

An angiotensin II (AT1) receptor antagonist

Uses

Olmesartan Acid (Olmesartan EP Impurity A) is an angiotensin II receptor antagonist. Used as an anti-hypertensive.

Definition

ChEBI: Olmesartan is a biphenylyltetrazole. It has a role as an antihypertensive agent and an angiotensin receptor antagonist.

General Description

Olmesartan medoxomil, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl-5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate (Benicar, Olmetec) uses the tetrazolering system as its acidic system, which participates inreceptor binding.When administered to a patient, the drugis rapidly and completely bioactivated by ester hydrolysis ofthe medoxomil during absorption from the gastrointestinaltract. Once the prodrug is converted to the active form, virtuallyno further metabolism occurs. In September 2007, theFood and Drug Administration (FDA) approved its use as acombination product with the calcium channel blocker amlodipinefor the management of hypertension. This combinationproduct is sold under the tradename of Azor.

Biochem/physiol Actions

Olmesartan possesses anti-inflammatory and anti-oxidative stress properties. It protects neuronal cells against oligomerized amyloid β (Aβ)-induced cellular senescence.

storage

Store at +4°C

Olmesartan(144689-24-7)Related Product Information

• Propyl butyrate
• Isopropyl alcohol
• Hydroxyethyl Cellulose
• N,N-Diisopropylethylamine
• Dextromethorphan
• Ethyl maltol
• Propyl gallate
• Dextromethorphan hydrobromide monohydrate
• Olmesartan Medoxomil
• Biphenyl
• CHLOROPHOSPHONAZO III
• Levamisole
• 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester
• Olmesartan
• 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE (INTERMEDIATE OF OLMESARTAN MEDOXOMIL)
• Olmesartan intermediate
• 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester
• Diethyl 2-propylImidazoledicarbonate