4-DIETHYLAMINO-2-METHOXY-BENZALDEHYDE Chemical Properties

Melting point:

73-76 °C

Boiling point:

334.8±27.0 °C(Predicted)

Density 

1.056±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

2.94±0.42(Predicted)

Appearance

Light yellow to brown Solid

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25

Safety Statements 

45

HazardClass 

IRRITANT

HS Code 

2922390090

4-DIETHYLAMINO-2-METHOXY-BENZALDEHYDE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 4-diethylamino-2-methoxy-benzaldehyde from 4-(diethylamino)salicylaldehyde and iodomethane was as follows: 4-diethylamino-2-hydroxybenzaldehyde (5.8 g, 30 mmol), potassium hydroxide (2 g, 35 mmol), and potassium carbonate (8.3 g, 60 mmol) were dissolved in acetonitrile (30 mL), and heated and stirred at 80 °C for for 10 min. Subsequently, iodomethane (3.5 mL, 56 mmol) was slowly added to the reaction system, and the reaction continued to be stirred at 80 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove insoluble impurities. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (sieve size 120-200 mesh) with the eluent ethyl acetate/hexane (1:3, v/v) to afford the target product 4-diethylamino-2-methoxy-benzaldehyde as a yellow solid in 85% yield. The structure of the product was confirmed by 1H NMR and 13C NMR: 1H NMR (500 MHz, CDCl3) δ 10.11 (s, 1H), 7.68 (dd, J = 8.9, 2.8 Hz, 1H), 6.26 (d, J = 8.8 Hz, 1H), 6.02 (s, 1H), 3.87 (s, 3H), 3.41 (dd, J = 6.9, 2.7 Hz, 4H), 1.21 (t, J = 5.4 Hz, 6H); 13C NMR (125 MHz, CDCl3) δ 187.1, 164.1, 153.8, 130.7, 114.2, 104.2, 92.4, 55.2, 44.7, 12.5.

References

[1] Journal of Physical Chemistry A, 2004, vol. 108, # 31, p. 6452 - 6454
[2] Dyes and Pigments, 2018, vol. 148, p. 474 - 491
[3] RSC Advances, 2013, vol. 3, # 46, p. 24021 - 24024
[4] Patent: US2017/320846, 2017, A1. Location in patent: Sheet 16

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