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(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE

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(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE Basic information

Product Name:
(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE
Synonyms:
  • ((2R,3R)-butane-2,3-diyl)bis(diphenylphosphane)
  • (R,R)-CHIRAPHOS
  • (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE
  • (2R,3R)-(+)-2,3-BIS(DIPHENYL PHOSPHINO)BUTANE
  • (2R,3R)-(+)-Bis(diphenylphosphino)butane, (R,R)-CHIRAPHOS
  • (R,R)-Chiraphos,97%
  • (2R,3R)-(+)-Bis(diphenylphosphino)butane, 98% (R,R)-CHIRAPHOS
  • (2R,3R)-(+)-2,3-Bis(diphenylphosphino)butane (R,R)-CHIRAPHOS
CAS:
74839-84-2
MF:
C28H28P2
MW:
426.48
Product Categories:
  • Chiral Phosphine
  • Pharmaceutical Intermediates
Mol File:
74839-84-2.mol
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(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE Chemical Properties

Melting point:
104-109 °C
Boiling point:
529.2±33.0 °C(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
color 
white
Sensitive 
Air Sensitive
CAS DataBase Reference
74839-84-2
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
36/37/39-26-37/39
WGK Germany 
3
TSCA 
No
HS Code 
29310099

MSDS

  • Language:English Provider:ACROS
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(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

(2R,3R)-Bis(diphenylphosphino)butane is a reagent used in the synthesis of endothelin A receptor antagonists. Also used in the synthesis of (R)-Tolterodine and (S)-Tolterodine.

Purification Methods

It recrystallises from absolute EtOH (~6g in 60mL) as colourless plates [Fryzuk & Bosnich J Am Chem Soc 99 6262 1977, Fryzuk & Bosnich J Am Chem Soc 101 3043 1979].

(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANESupplier

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