1,8-Naphthyridine Chemical Properties

Melting point:

99.8-99.9°C

Boiling point:

248.9±13.0 °C(Predicted)

Density 

1.183±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

3.39

form 

powder to crystal

pka

3.55±0.10(Predicted)

color 

White to Light yellow to Light orange

InChIKey

FLBAYUMRQUHISI-UHFFFAOYSA-N

CAS DataBase Reference

254-60-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2902900000

1,8-Naphthyridine Usage And Synthesis

Description

1,8-Naphthyridine is an organic compound with the formula C8H6N2. It is the most well-studied of the six isomeric naphthyridines, a subset of diazanaphthalenes with nitrogen in the separate rings. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.

Uses

1,8-naphthyridine (napy) and its simplest 2-methyl and 2,7-dimethyl derivatives may act as monodentate and bidentate ligands, resembling the behavior of the carboxylate ligands.

Definition

ChEBI: 1,8-naphthyridine is a naphthyridine in which the nitrogens are situated at positions 1 and 8.

Purification Methods

Purify 1,8-naphthyridine through an Al2O3 column and elute with toluene and pet ether, evaporate the eluate, crystallise the residue from pet ether (b 60-80o), and sublime it at 80o/13mm. The picrate [15936-16-0] has m 207-208o (from EtOH), and the methiodide has m 180-181o (from EtOH). [Hawes & Wibberley J Chem Soc (C) 1564 1967, UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 134 1971, Beilstein 23 II 178, 23 III/IV 1237.]

1,8-Naphthyridine(254-60-4)Related Product Information

• 1,8-Naphthyridine
• 7,10-dichloro-2-methoxybenzo[b]-1,5-naphthyridine
• 5,6,7,8-TETRAHYDRO-6-(PHEHYLMETHYL)-1,6-NAPHTHYRIDIN-3-AMINE
• 3-(CHLOROMETHYL)-6-(TRIFLUOROMETHYL)PYRIDINE
• 3-ACETYL-2-METHYL-1,6-NAPHTHYRIDINE
• 3-BROMO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE
• 2-CHLORO-1,8-NAPHTHYRIDINE
• 5-Bromo-1,2,3,4-tetrahydro-[1,7]naphthyridine
• 5-CHLORO-1,6-NAPHTHYRIDINE
• 5-chloro-1,2,3,4-tetrahydro-1,6-naphthyridine
• 5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDIN-3-OL
• 4-HYDROXY-1,5-NAPHTHYRIDINE
• 4-HYDROXY-1,5-NAPHTHYRIDINE-3-CARBOXYLIC ACID
• 1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-
• 2,7-NAPHTHYRIDINE, 1-CHLORO-
• 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester
• Nalidixic acid sodium salt
• 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid