Hydantoin Chemical Properties

Melting point:

218-220 °C (lit.)

Boiling point:

187.47°C (rough estimate)

Density 

1.4457 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.5110 (estimate)

storage temp. 

Store below +30°C.

solubility 

SLIGHTLY SOLUBLE

pka

pKa 9.1 (Uncertain)

form 

Fine Powder

color 

White to light yellow

Water Solubility 

SLIGHTLY SOLUBLE

Merck 

14,4760

BRN 

110598

LogP

-1.69

CAS DataBase Reference

461-72-3(CAS DataBase Reference)

NIST Chemistry Reference

2,4-Imidazolidinedione(461-72-3)

EPA Substance Registry System

2,4-Imidazolidinedione (461-72-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36/37/39-27-26

WGK Germany 

3

RTECS 

MT8210000

TSCA 

Yes

HS Code 

29332100

MSDS

• Language:English Provider:2,4-Imidazolinedione
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Hydantoin Usage And Synthesis

Chemical Properties

White Solid

Uses

The product has been used as a substrate (at 40 °C and pH 9.0) to determine the D-hydantoinase activity in adzuki bean extract.

Uses

Reactant for synthesis of: N-benzyl aplysinopsin analogs as anticancer agents, D-glutamic acid based inhibitors, Antidiabetic chromonyl-2,4-thiazolidinediones, GSK-3β, inhibitors with brain permeability, Thiazolidinedione derivatives as 15-PGDH inhibitors, and Radio-sensitizing agents.

Definition

ChEBI: Hydantoin is an imidazolidine-2,4-dione.

Pharmaceutical Applications

Control of generalized convulsive status epilepticus; prevention and treatment of seizures during neurosurgery; short-term substitute for oral phenytoin.

Mechanism of action

Hydantoins are a class of drugs mainly used to treat seizures (anticonvulsant or antiepileptic drugs). Hydantoins reduce seizures by targeting the sodium channel present throughout the nerves. Activation of sodium channels results in the conduction of electrical impulses and the release of neurotransmitters. It could stabilise neuronal membranes by decreasing sodium and calcium ion influx into the neurons. Also decreases post-tetanic potentiation and repetitive discharge.

Pharmacokinetics

Completely absorbed after IM administration. Protein binding: 95%–99%. Rapidly and completely hydrolyzed to phenytoin after IM or IV administration. Time of complete conversion to phenytoin: 4 hr after IM injection; 2 hr after IV infusion. Half-life: 8–15 min (for conversion to phenytoin).

Hydantoin(461-72-3)Related Product Information

• Imidazolidinyl urea
• N-Vinyl-2-pyrrolidone
• Polyvinylpyrrolidone
• 1,3-Dibromo-5,5-dimethylhydantoin
• Ketoprofen
• Phenytoin sodium
• Imidazolidine
• Ethyltrichlorosilane
• tert-Butyl acetate
• Abiraterone acetate
• Ethylmagnesium bromide
• 2-Imidazolidone
• dehydroleucine
• 5 - (1-hydroxy-2-methylpropyl) hydantoin
• 4-methyl-2-oxopentadide
• 3-methyl-2-oxopentadide
• Iprodione
• Halogenated hydantoin