Nipecotic acid Chemical Properties

Melting point:

261 °C (dec.) (lit.)

Boiling point:

239.22°C (rough estimate)

Density 

1.1426 (rough estimate)

refractive index 

1.4587 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

water: soluble50mg/mL, clear, colorless to faintly yellow

form 

Solid

pka

pK1:3.35(+1);pK2:10.64(0) (25°C)

color 

White

Water Solubility 

Soluble in water

Merck 

14,6560

BRN 

81096

CAS DataBase Reference

498-95-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

TM6125380

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Nipecotic acid Usage And Synthesis

Chemical Properties

off-white to pale yellow-beige powder

Uses

(+/-)-Nipecotic Acid (cas# 498-95-3) is a compound useful in organic synthesis.

Definition

ChEBI: A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group.

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 602, 1963 DOI: 10.1021/jo01037a531

General Description

R(?)-Nipecotic acid is a potential inhibitor of uptake of γ-aminobutyric acid (GABA) in rat brain slices. Lipophilic derivatives of nipecotic acid are used as drugs for the treatment of epilepsy.

Nipecotic acid(498-95-3)Related Product Information

• Ethyl 2-(Chlorosulfonyl)acetate
• Haloperidol
• 2,2,6,6-Tetramethyl-4-piperidinol
• DROPERIDOL
• Folic acid
• Citric acid
• Hyaluronic acid
• Triacetonediamine
• Ascoric Acid
• Diphenoxylate
• NIPECOTIC ACID ETHYL ESTER
• Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride
• N-Methyl-3-carbomethoxy-4-piperidone hydrochloride
• 2,5-DIBROMOPIPERIDINE
• 3-CARBETHOXY-2-PIPERIDONE
• 4-OXO-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER
• BENZOYLECGONINE
• 1-BENZYL-3-METHOXYCARBONYL-4-PIPERIDONE