AG 18 Chemical Properties

Melting point:

225°C

Boiling point:

421.1±45.0 °C(Predicted)

Density 

1.428±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in DMSO, ethanol, or DMF

pka

7.26±0.18(Predicted)

form 

Yellow solid

color 

Yellow

λmax

464nm(DMSO)(lit.)

Stability:

Store in refrigerator

Safety Information

WGK Germany 

3

HS Code 

2926.90.5050

MSDS

• Language:English Provider:SigmaAldrich

AG 18 Usage And Synthesis

Chemical Properties

Yellow Powder

Uses

AG 18 inhibits EGFR with IC50 of 35 μM.

Uses

A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).

Definition

ChEBI: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile is a member of catechols.

Biological Activity

Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

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