4-Biphenylcarboxylic acid Chemical Properties

Melting point:

220-225 °C(lit.)

Boiling point:

295.53°C (rough estimate)

Density 

1.1184 (rough estimate)

refractive index 

1.5954 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

0.03g/l

form 

Crystalline Powder

pka

4.19±0.10(Predicted)

color 

White to beige

Water Solubility 

Insoluble in water.

BRN 

973519

InChI

1S/C13H10O2/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,(H,14,15)

InChIKey

NNJMFJSKMRYHSR-UHFFFAOYSA-N

SMILES

OC(=O)c1ccc(cc1)-c2ccccc2

CAS DataBase Reference

92-92-2(CAS DataBase Reference)

NIST Chemistry Reference

[1,1'-Biphenyl]-4-carboxylic acid(92-92-2)

EPA Substance Registry System

[1,1'-Biphenyl]-4-carboxylic acid (92-92-2)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22-51-36-22

Safety Statements 

37/39-26-36

WGK Germany 

1

RTECS 

DV1925100

Hazard Note 

Irritant

TSCA 

TSCA listed

HS Code 

29163900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2

MSDS

• Language:English Provider:4-Biphenylcarboxylic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Biphenylcarboxylic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

Biphenyl-4-carboxylic acid is employed in the synthesis, characterization of europium, terbium complexes.

Synthesis Reference(s)

Synthetic Communications, 25, p. 3695, 1995 DOI: 10.1080/00397919508015507

Safety Profile

Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.

Synthesis

Under argon protection, 2.75 g (13.8 mmol) of 4-bromobenzoic acid, 2 g (16.4 mmol) of phenylboronic acid, 32.71 g (27.3 mmol) of K2CO, and 0.2 g of palladium tetrakis(triphenylphosphine) were added to 40 mL of dioxyhexahydroxane solvent/water (10:1), and heated up to 75 ??C, and the reaction was completely monitored by TLC after 5h. The reaction solution was cooled, filtered, adjusted PH to 2-3, a large amount of white solid was generated, filtered to obtain a white solid 4-biphenylcarboxylic acid 2.30 g, yield 84.9%.

Purification Methods

Crystallise the acid from *C6H6/pet ether or aqueous EtOH. [Beilstein 9 IV 2479.]

4-Biphenylcarboxylic acid(92-92-2)Related Product Information

• 2,3,4-Trihydroxybenzoic acid
• 2'-Hydroxy-3-phenylpropiophenone
• 4-Methoxybenzoic acid
• Benzyl benzoate
• Terephthalic acid
• 2,4-Dichlorobenzoic acid
• 2,3,3',4,4',5-HEXACHLOROBIPHENYL
• 4-Nitrobenzoic acid
• Methyl 4-tert-butylbenzoate
• Benzoic acid
• Bifonazole
• p-Toluic acid
• Biphenyl
• Bifendate
• Methylparaben
• Biphenyl-4,4'-dicarboxylic acid
• trans-Bifenthtin
• Estradiol benzoate