10,12-TRICOSADIYNOIC ACID
10,12-TRICOSADIYNOIC ACID Basic information
- Product Name:
- 10,12-TRICOSADIYNOIC ACID
- Synonyms:
-
- 10,12-TRICOSADIYNOIC ACID
- TIMTEC-BB SBB009036
- tricosa-10,12-diynoic acid
- 10,12-Tricosadiynoic acid >=98.0% (GC)
- 10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%10,12-TRICOSADIYNOIC ACID, 97%
- 10,12-Tricosadiynoicaci
- 10,12-Tricosadiynoic acid,ROS,mono- acylglycerol acyltransferase,10,12Tricosadiynoic acid,fatty,Diacylglycerol acyltransferase,SIRT1-AMPK,Diglyceride acyltransferase,metabolic,mitochondrial,oxidation,insulin,10,12 Tricosadiynoic acid,inhibit,triglyceride,Inhibitor,Acyltransferase,acyl-CoA:cholesterol acyltransferase,acid
- 10,12-Tricosadiynoic acid - [T94776]
- CAS:
- 66990-30-5
- MF:
- C23H38O2
- MW:
- 346.55
- Product Categories:
-
- Acetylenes
- Acetylenic Carboxylic Acids & Their Derivatives
- Diacetylene Monocarboxylic Acids
- Functional Materials
- LB Films
- Mol File:
- 66990-30-5.mol
10,12-TRICOSADIYNOIC ACID Chemical Properties
- Melting point:
- 56-60 °C
- storage temp.
- Refrigerator
- solubility
- DMSO : 100 mg/mL (288.56 mM）
- form
- Solid
- color
- White to off-white
- Water Solubility
- Insoluble in water.
- Sensitive
- Light Sensitive
- BRN
- 1880414
- CAS DataBase Reference
- 66990-30-5(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
10,12-TRICOSADIYNOIC ACID Usage And Synthesis
Uses
It is an active pharmaceutical intermediate.
Definition
ChEBI: 10,12-tricosadiynoic acid is a very long-chain fatty acid.
in vivo
10,12-Tricosadiynoic acid (100 μg/kg; oral gavage; daily; for 8 weeks; male Wistar rats) treatment increases hepatic mitochondrial fatty acid oxidation (FAO) via activation of the SIRT1-AMPK (adenosine 5′-monophosphate-activated protein kinase) pathway and proliferator activator receptor α and reduces hydrogen peroxide accumulation in high fat diet-fed rats, which significantly decreases hepatic lipid and ROS contents, reduces body weight gain, and decreases serum triglyceride and insulin levels[1].
10,12-Tricosadiynoic acid (0 mg/kg, 37.5 mg/kg, 75 mg/kg, and 150 mg/kg diet) treatment does not affect weight gain, but significantly decreases peroxisomal β-oxidation in the liver, and increased body fat accumulation in Nile tilapia. The fish with impaired peroxisomal β-oxidation exhibited higher contents of serum lipid and peroxidation products, and alanine aminotransferase activity, and significantly lowered hepatic activities of superoxide dismutase and catalase[3].
| Animal Model: | Male Wistar rats (210-230 g) fed with high fat diet[1] |
| Dosage: | 100 μg/kg |
| Administration: | Oral gavage; daily; for 8 weeks |
| Result: | Reduced hydrogen peroxide accumulation in high fat diet-fed rats, which significantly decreased hepatic lipid and ROS contents, reduced body weight gain, and decreased serum triglyceride and insulin levels. |
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