HUMAN G-CSF Chemical Properties

storage temp. 

−20°C

form 

lyophilized powder

color 

white to off-white

biological source

mouse

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

HS Code 

3504009000

MSDS

• Language:English Provider:SigmaAldrich

HUMAN G-CSF Usage And Synthesis

Uses

Granulocyte colony-stimulating factor human has been used:

• in culturing human neutrophils
• as a growth factor component of double layer granulocyte-macrophage colony-forming unit (CFU-GM) culture system for CD34⁺ cells
• to test its protective effects chronic liver damage model

General Description

Granulocyte colony-stimulating factor human (GCSF) gene is mapped to human chromosome 17q21.1. Structurally, GCSF comprises a four α-helical bundle.

Biochem/physiol Actions

Granulocyte colony-stimulating factor human (GCSF) interacts specifically with the immunoglobin (Ig) domain of the granulocyte colony-stimulating factor receptor (GCSFR).

Description

Granulocyte Colony Stimulating Factor Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 175 amino acids and having a molecular mass of 18.8 KD.
GCSF is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

GCSF is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different isoforms have been found for the GCSF gene. Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This csf induces granulocytes.

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