5-Bromo-4-cyclopropyl-6-methoxypyrimidine Chemical Properties

Boiling point:

289.3±40.0 °C(Predicted)

Density 

1.590±0.06 g/cm3(Predicted)

pka

2.13±0.28(Predicted)

InChI

InChI=1S/C8H9BrN2O/c1-12-8-6(9)7(5-2-3-5)10-4-11-8/h4-5H,2-3H2,1H3

InChIKey

FHEYKQYHQQAZBJ-UHFFFAOYSA-N

SMILES

C1=NC(OC)=C(Br)C(C2CC2)=N1

5-Bromo-4-cyclopropyl-6-methoxypyrimidine Usage And Synthesis

Synthesis

To a solution of 4-cyclopropyl-6-methoxypyrimidine (1.6 g, 10.7 mmol) in EtOH (10 mL) was added Bn (1.87 g, 11.7 mmol) at -20 °C. The resulting mixture was slowly warmed to room temperature and stirred at the same temperature for 16 h. Solvent was removed under reduced pressure and the residue dissolved in EtOAc and washed with saturated Na2C03, water and brine. The organic layer was dried over Na2SO4 and concentrated to give 5-bromo-4-cyclopropyl-6-methoxypyrimidine (2.3 g).