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CORTISTATIN-14

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CORTISTATIN-14 Basic information

Product Name:
CORTISTATIN-14
Synonyms:
  • H-PRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS-OH
  • CST-14
  • CST-14 (RAT)
  • CORTISTATIN (RAT)
  • CORTISTATIN-14
  • CORTISTATIN-14 (MOUSE, RAT)
  • CORTISTATIN (16-29)
  • (DES-ALA1,PRO2,SER12)-SOMATOSTATIN-14-LYS
CAS:
186901-48-4
MF:
C81H114N20O18S2
MW:
1720.03
Product Categories:
  • Peptide
  • Somatostatin receptor
Mol File:
186901-48-4.mol
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CORTISTATIN-14 Chemical Properties

Boiling point:
2012.6±65.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
1% acetic acid: 1mg/mL, clear, colorless
pka
12.47±0.70(Predicted)
form 
Solid
color 
White to off-white
Sequence
{Pro}{Cys}{Lys}{Asn}{Phe}{Phe}{Trp}{Lys}{Thr}{Phe}{Ser}{Ser}{Cys}{Lys}-NH2 (Disulfide bridge: Cys2-Cys13)
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Safety Information

WGK Germany 
3

MSDS

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CORTISTATIN-14 Usage And Synthesis

Uses

Cortistatin-14 may be used in competition binding assay with sst4 receptors (CHO-sst4) of CHO cells and sst1 receptors (CHO-sst1).

Biological Activity

Cortistatin-14, like somatostatin inhibits the physiological activity of hippocampal neurons. It binds and exerts its function through all the somatostatin receptors (sst1-sst5). It shows anticonvulsive and neuroprotective effect. Cortistatin-14 has remarkable anti-inflammatory properties.', 'Somatostatin-like neuropeptide with neuronal depressant and sleep modulating properties. Exogenous cortistatin impairs short-term memory processing.

in vivo

Cortistatin-14 (10-250 μg/kg; injected in the footpad or intraperitoneal injection; six times a day) reduces acute neurogenic plasma protein leakage in the hind paw skin of rats caused by mustard oil, as well as carrageenan-induced paw edema in mice, mechanical hyperalgesia, the production of IL-1β and tumor necrosis factor-α, and mild heat injury-induced thermal hyperalgesia[1].
Cortistatin-14 (10 μg; intravenous injection; single dose) plays a regulatory role in the pituitary secretion of male rats[2].
Cortistatin-14 (1-10 nM, intracerebroventricular injection; single dose) has anticonvulsant and neuroprotective effects in rats by binding to somatostatin receptors, which leads to a reduction in the release of excitatory neurotransmitters[3].

Animal Model:Hydrochloride-induced rat[3]
Dosage:1 and 10 nM; single dose
Administration:Intracerebroventricular injection (ICV)
Result:Relieved epilepsy, inhibited neuronal loss, prevented the reduction of immune-active somatostatin and its receptors in the hippocampus, and reduced the release of 3H-D-aspartate under stimulation.
Animal Model:Endotoxin-stimulated mice[1]
Dosage:10 μg/kg (i.p.); 100 μg/kg (i.p.); 250 μg/kg (i.pl.); six times a day
Administration:Intraperitoneal injection (i.p.); i.pl.
Result:Reduced the concentrations of TNF-α and IL-1β, reduced mustard oil-induced plasma protein extravasation in the dorsal skin, with an inhibition rate of nearly 80%, inhibited plantar thermal hyperalgesia in rats caused by mild thermal injury (51°C, 20 seconds).
Animal Model:Wistar-Kyoto rat[2]
Dosage:10 μg; single dose
Administration:Intravenous injection (i.v.)
Result:Reduced growth hormone concentrations without affecting LH and FSH concentrations.

IC 50

SSTR1; SSTR2; SSTR3; SSTR4; SSTR5

CORTISTATIN-14Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Email
3007715519@qq.com
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