25-DESACETYL RIFAMPICIN Chemical Properties

Melting point:

>300°C

Boiling point:

943.1±65.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

Amber Vial, -20°C Freezer, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

4.96±0.70(Predicted)

color 

Dark Red to Black

Stability:

Light Sensitive

InChIKey

KUJZTIJOBQNKDR-ACYBWPGYNA-N

25-DESACETYL RIFAMPICIN Usage And Synthesis

Description

25-desacetyl rifampicin, also known as 25-deacetyl-rifampicin, is the main metabolite of rifampicin. It has partial activity. Rifampicin mainly treats various forms of tuberculosis. High-Performance Liquid Chromatographic can be used to determine the metabolism of rifampicin in the body by checking the concentration of 25-desacetyl rifampicin in the urine or blood of tuberculosis patients[1-3].

Chemical Properties

Dark Red Solid

Uses

A metabolite of Rifampicin.

References

[1]Chik Z, et al. A bioequivalence comparison of two formulations of rifampicin (300- vs 150-mg capsules): An open-label, randomized, two-treatment, two-way crossover study in healthy volunteers. Clinical Therapeutics, 2011.
[2] Mohan B, et al.Evaluation of the recently reported USP gradient HPLC method for analysis of anti-tuberculosis drugs for its ability to resolve degradation products of rifampicin. Journal of Pharmaceutical and Biomedical Analysis, 2003; 31: 607-612.
[3] Lily, et al. The influence of mutation gene rpoB of Mycobacterium tuberculosis cluster I (507-534) on the elimination 25-desacetyl rifampicin in urine of tuberculosis subjects. IOP Conference Series: Earth and Environmental Science, 2018; 1755-1315.

25-DESACETYL RIFAMPICIN(16783-99-6)Related Product Information

• 25-DESACETYL RIFAMPICIN
• Rifampicin
• RIFAMPIN, [4-METHYLPIPERAZINE-3H]-
• RIFAMPICIN-N-OXID
• 25-DESACETYL RIFAPENTINE
• rifampicin N-oxide
• Rifapentine hydrochloride