3-[(1S)-1-(Dimethylaminoethyl)]phenol CAS#: 139306-10-8

3-[(1S)-1-(Dimethylaminoethyl)]phenol Basic information

Product Name:

3-[(1S)-1-(Dimethylaminoethyl)]phenol

Synonyms:

3-[(1S)1-(DIMETHYLAMINO)ETHYL]PHENOL(INTERMEDIATEOFRIVASTIGMINE)
(S)-3-(1-N,N-DIMETHY(AMINO)ETHYL PHENOL
(1S)-3-[-1-(Dimethylaminoethyl)]phenol
Rivastigmine-3-(1-(dimethylamino)ethyl)phenol
(S)-3-(1-N,N-dimethylaminoethyl) phenol
(S)-3-1(1-(Dimethylamino)ethylphenol
RivastigMine Metabolite (NAP 226-90)
3-[(1(S)-N,N-DiMethylaMino)Ethyl] Phenol

CAS:

139306-10-8

MF:

C10H15NO

MW:

165.23

EINECS:

1308068-626-2

Product Categories:

Intermediate of Rivastigmine
Metabolite Reference Standard
Chiral Reagents
Intermediates & Fine Chemicals
Metabolites & Impurities
Pharmaceuticals

Mol File:

139306-10-8.mol

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3-[(1S)-1-(Dimethylaminoethyl)]phenol Chemical Properties

Melting point:: 87-88°C
Boiling point:: 241℃
Density: 1.021
Flash point:: 97℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.86±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C10H15NO/c1-8(11(2)3)9-5-4-6-10(12)7-9/h4-8,12H,1-3H3/t8-/m0/s1
InChIKey: GQZXRLWUYONVCP-QMMMGPOBSA-N
SMILES: C1(O)=CC=CC([C@@H](N(C)C)C)=C1
CAS DataBase Reference: 139306-10-8(CAS DataBase Reference)

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Safety Information

Risk Statements: 36-43
Safety Statements: 26-36/37/39
HS Code: 29222990

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3-[(1S)-1-(Dimethylaminoethyl)]phenol Usage And Synthesis

Description

NAP 226-90 is a metabolite of rivastigmine that is formed by hydrolysis.

Chemical Properties

off-white to pale yellow crysta

Uses

NAP 226-90 (Rivastigmine EP Impurity A; Rivastigmin USP Related Compound C) is a S-Enantiomer metabolite of Rivastigmine, a brain selective acetylcholinesterase inhibitor.

References

[1] MD R J P. Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of alzheimer’s disease[J]. Clinical therapeutics, 1998, 20 4: Pages 634-647. DOI: 10.1016/s0149-2918(98)80127-6

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