3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Chemical Properties

Melting point:

292-293℃ (ethanol )

Boiling point:

522.8±45.0 °C(Predicted)

Density 

1.570±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

Soluble to 100 mM in DMSO

form 

Red solid

pka

7.40±0.50(Predicted)

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN 2811 6.1 / PGIII

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Usage And Synthesis

Description

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC₅₀s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC₅₀ = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.

Uses

Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.?Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents.

Definition

ChEBI: 2H-pyrazolo[4,3-b]quinoxalin-3-amine is a quinoxaline derivative.

Biological Activity

Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE(40254-90-8)Related Product Information

• Brimonidine Impurity 6 Sodium Salt
• 5-Bromoquinazolin-6-ylthiourea
• 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
• BriMonidine-2,3-dione
• Brimonidine Impurity 7
• Brimonidine Related Impurity 3
• 1H-PYRAZOLO[3,4-B]PYRAZIN-3-AMINE
• 4,7-DIAZA-1H-INDAZOLE
• 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE