Choline hydroxide Chemical Properties

Melting point:

236～239℃

Density 

1.09 g/mL at 20 °C

vapor pressure 

28.284hPa at 25℃

refractive index 

n20/D 1.4304

Flash point:

92 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

Water (easy), ethanol (difficult to dissolve (1-pentanol)), ether (insoluble)

form 

Granular Powder

pka

13.9(at 25℃)

color 

White

Water Solubility 

miscible

Merck 

14,2204

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

InChI

1S/C5H14NO.H2O/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H2/q+1;/p-1

InChIKey

KIZQNNOULOCVDM-UHFFFAOYSA-M

SMILES

[OH-].C[N+](C)(C)CCO

LogP

-2.25 at 25℃

CAS DataBase Reference

123-41-1(CAS DataBase Reference)

EPA Substance Registry System

Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide (123-41-1)

Safety Information

Hazard Codes 

C,T

Risk Statements 

34-35-43-39/23/24/25-23/24/25-10-R35

Safety Statements 

26-36/37/39-45-S45-S36/37/39-S26

RIDADR 

UN 3286 3/PG 2

WGK Germany 

1

RTECS 

GA4025500

F 

8-9-23

TSCA 

TSCA listed

HazardClass 

8

PackingGroup 

II

HS Code 

29231000

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Carc. 1B
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1A
STOT SE 1

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Choline hydroxide Usage And Synthesis

Description

Choline hydroxide or choline base is also known as 2-hydroxyl ethyl trimethyl ammonium hydroxide. It is a strong yet organic base.
Choline hydroxide is primarily used to produce other choline salts, which could be used in nutraceuticals, baby food, etc.  Choline hydroxide can be used as phase transfer catalysts which carry the hydroxide ion into organic systems. It is used as an ingredient in cleaning and developer formulations in the electronics and printed circuit board industry and in paint stripping formulations. It can also be used as corrosion inhibitor, for the H2S removal from gas streams. Furthermore, it is used as the cleaning and degreasing agent in the metal industry.

References

[1] Patent US20160068476: Process for choline hydroxide
[2] https://en.wikipedia.org/wiki/Choline

Chemical Properties

clear light yellow viscous solution

Uses

Choline hydroxide is used as a precursor molecule for the neurotransmitter acetylcholine, it is involved in several functions including muscle and memory muscle control. It was used as a basic catalyst for aldol condensation reactions.

Uses

Choline hydroxide solution has been used in the synthesis of choline hexafluoroacetylacetonate that can be used as an extractant along with bis-(trifluoromethylsulfonyl)imide ionic liquid for the homogeneous liquid-liquid extraction of neodymium(III).

Definition

An amino alcohol,CH₂OHCH₂N(CH₃)₃OH. It occurswidely in living organisms as aconstituent of certain types ofphospholipids– the lecithins andsphingomyelins– and in the neurotransmitteracetylcholine. It issometimes classified as a memberof the vitamin B complex.

Flammability and Explosibility

Non flammable

Synthesis

A method for preparing high purity choline from choline chloride, said method being carried out in the following steps:

1) pretreating a strongly acidic cation exchange resin, said pretreatment process being: acid treatment, ultrapure water treatment to neutrality, alkali treatment, ultrapure water treatment to neutrality, and then repeating the steps of acid treatment/ultrapure water treatment more than two times, and ultimately rinsing with a large amount of ultrapure water, to obtain strongly acidic cation exchange resin columns after pretreatment;

2) passing an aqueous choline chloride solution through at least one set of strongly acidic cation exchange resin columns after pretreatment to remove cation impurities therein;

3) passing the aqueous choline chloride solution through the strongly acidic cation exchange columns through a bipolar membrane electrodialysis treatment to obtain an aqueous choline solution and a hydrochloric acid solution;

4) The strongly basic anion exchange resin column is pretreated, and the pretreatment process is in the following order: alkali treatment, ultrapure water treatment to neutrality, acid treatment, ultrapure water treatment to neutrality, and then repeating the alkali treatment/ultrapure water treatment step more than two times, and ultimately rinsing with a large amount of ultrapure water, to obtain the pretreated strongly basic anion exchange resin column;

5) passing the aqueous solution of choline obtained in step 3) through the At least one set of pretreated strongly basic anion exchange resin columns to remove the anion impurities therein, and then distill and concentrate the obtained aqueous choline solution under reduced pressure to a desired concentration to obtain an ultrapure aqueous choline solution.

Choline hydroxide(123-41-1)Related Product Information

• Benzyltrimethylammonium hydroxide
• Tetramethylammonium hydroxide pentahydrate
• Sodium hydroxide
• Tetraethylammonium hydroxide
• Aluminum hydroxide
• 2-(METHYLSULFONYL)ETHANOL
• Hydroxyethyl Cellulose
• Hydroxyethyl starch
• Lithium hydroxide monohydrate
• Sodium isethionate
• 2-(2-Aminoethylamino)ethanol
• Tetraethylammonium bromide
• Ammonium hydroxide
• Citicoline sodium
• choline,tartrate(1:1)sal
• 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)CARBODIIMIDE METHO-P-TOLUENESULFONATE
• TETRAETHANOL AMMONIUM HYDROXIDE
• Lecithin
• Choline Hydroxide Solution