(S)-TERT-BUTYL 1-(CHLOROMETHYL)-5-HYDROXY-1H-BENZO[E]INDOLE-3(2H)-CARBOXYLATE Chemical Properties

Melting point:

161 °C (decomp)

Boiling point:

493.7±45.0 °C(Predicted)

Density 

1.275±0.06 g/cm3(Predicted)

storage temp. 

-20°C

form 

powder

pka

9.63±0.40(Predicted)

optical activity

[α]/D -89.0, c = 0.05% in chloroform

Safety Information

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

(S)-TERT-BUTYL 1-(CHLOROMETHYL)-5-HYDROXY-1H-BENZO[E]INDOLE-3(2H)-CARBOXYLATE Usage And Synthesis

Uses

N-Boc-CBI best used as its seco precursor (seco-N-Boc-CBI) is a simple alkylation subunit analog of that found in the naturally occurring antitumor agents the duocarmycins, yatakemycin, and CC-1065, which act by sequence selective DNA alkylation.