4-Aminobenzotrifluoride Chemical Properties

Melting point:

3-8 °C

Boiling point:

83 °C12 mm Hg(lit.)

Density 

1.283 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.483(lit.)

Flash point:

188 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Liquid

pka

2.45(at 25℃)

Specific Gravity

1.283

color 

Clear colorless to yellow

Water Solubility 

<0.1 g/100 mL

Sensitive 

Air Sensitive

BRN 

1564853

InChIKey

ODGIMMLDVSWADK-UHFFFAOYSA-N

LogP

1.95 at 20℃

CAS DataBase Reference

455-14-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzenamine, 4-(trifluoromethyl)-(455-14-1)

EPA Substance Registry System

4-(Trifluoromethyl)aniline (455-14-1)

Safety Information

Hazard Codes 

T,N,Xi,Xn

Risk Statements 

25-36-50/53-36/37/38-33-20/21/22

Safety Statements 

26-45-60-61-36/37/39-36

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

3

RTECS 

XU9260000

Hazard Note 

Toxic/Irritant

TSCA 

T

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214300

MSDS

• Language:English Provider:4-(Trifluoromethyl)aniline
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Aminobenzotrifluoride Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

4-Substituted aniline derivatives exert special hematotoxicity on the red blood cells and induce leukocytosis.

Uses

4-(Trifluoromethyl)aniline was used in the synthesis of 4-(trialkylmethyl)anilines. It was also used as a synthetic building block.

Definition

ChEBI: A substituted aniline that is a benzene ring substituted with an amino group at position 1 and a trifluoromethyl group at position 4.

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 2873, 1989 DOI: 10.1021/jo00273a020

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

4-Aminobenzotrifluoride(455-14-1)Related Product Information

• 3-(Trifluoromethyl)benzaldehyde
• p-Toluidine
• 4-(Trifluoromethoxy)aniline
• N,N-Dimethylaniline
• 4-(Trifluoromethyl)cinnamic acid
• 4'-(Trifluoromethyl)acetophenone
• 4-Fluoroaniline
• 2,5-Bis(trifluoromethyl)aniline
• N-Methylaniline
• Acid Blue 93
• Aniline
• 4-(Trifluoromethylthio)aniline
• N,N-Dimethyl-1,4-phenylenediamine
• 4'-(Octyloxy)-4-biphenylcarbonitrile
• 4-Trifluoromethylphenol
• 4-(Trifluoromethoxy)benzoic acid
• 4-(Trifluoromethoxy)benzyl chloride
• 4-(Trifluoromethyl)phenylacetic acid