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DIPERODON HYDROCHLORIDE

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DIPERODON HYDROCHLORIDE Basic information

Product Name:
DIPERODON HYDROCHLORIDE
Synonyms:
  • 3-piperidino-1,2-propanedioldicarbanilatehydrochloride
  • diothanehydrochloride
  • Diperodon HCl
  • 3-(1-PIPERIDINYL)-1,2-PROPANEDIOL BIS(PHENYLCARBAMATE)
  • 3-[1-PIPERIDINYL]-1,2-PROPANEDIOL BIS[PHENYLCARBAMATE] HYDROCHLORIDE
  • DIPERODON HYDROCHLORIDE
  • 1,2-propanediol,3-(1-piperidinyl)-,bis(phenylcarbamato)(ester),monohydroc
  • 1,2-propanediol,3-piperidino-,dicarbanilate,hydrochloride
CAS:
537-12-2
MF:
C22H28ClN3O4
MW:
433.93
EINECS:
208-659-8
Product Categories:
  • TANTUM
Mol File:
537-12-2.mol
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DIPERODON HYDROCHLORIDE Chemical Properties

Melting point:
193-201°C
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Methanol (Slightly)
color 
White
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
RTECS 
TZ1101000
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DIPERODON HYDROCHLORIDE Usage And Synthesis

Originator

Diothane Hydrochloride,HMR

Uses

analgesic, antipyretic, antiinflammatory

Uses

Diperodon Hydrochloride is an inhibitor of ebola virus (EBOV) and marburg virus (MARV) by an antiviral activity of the G protein-coupled receptor (GPCR) antagonist.

Manufacturing Process

15.0 g phenylisocyanate in 100 ml of anhydrous ether are added to 10 g of N- (1,2-dihydroxypropyl)-piperidine (prepared from glycide and piperidine) and the solution boiled for two hours, after which it is cooled and saturated with dry hydrogen chloride gas. The ether layer is then decanted off and the remaining insoluble product is dissolved in a hot mixture of acetone and ethyl acetate which on cooling precipitates white crystals of the hydrochloride of the ester of 1,2-propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate); MP 197°- 198°C. A base form may be prepared by adding an equivalent of triethyl amine.

Therapeutic Function

1,2-Propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate) (ester), hydrochloride

DIPERODON HYDROCHLORIDESupplier

MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Email
isunpharm@qq.com
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Email
3003855609@qq.com
Musechem
Tel
+1-800-259-7612
Email
info@musechem.com
Aikon International Limited
Tel
025-58851090 13611564524
Email
lwan@aikonchem.com