N-Isopropylaniline Chemical Properties

Melting point:

-32°C

Boiling point:

55 °C0.3 mm Hg(lit.)

Density 

0.934 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.539(lit.)

Flash point:

185 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

pka

5.77(at 25℃)

Specific Gravity

0.94

color 

Colorless to Orange to Green

Water Solubility 

<0.01 g/100 mL at 21 ºC

BRN 

2205871

Exposure limits

ACGIH: TWA 2 ppm (Skin)
NIOSH: IDLH 100 ppm; TWA 2 ppm(10 mg/m3)

CAS DataBase Reference

768-52-5(CAS DataBase Reference)

NIST Chemistry Reference

N-Isopropylaniline(768-52-5)

EPA Substance Registry System

N-Isopropylaniline (768-52-5)

Safety Information

Hazard Codes 

T

Risk Statements 

22-23-36/37/38

Safety Statements 

26-36-45-7/9

RIDADR 

2810

OEB

B

OEL

TWA: 2 ppm (10 mg/m3) [skin]

WGK Germany 

3

RTECS 

BY4190000

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29214990

Hazardous Substances Data

768-52-5(Hazardous Substances Data)

MSDS

• Language:English Provider:N-Phenylisopropylamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N-Isopropylaniline Usage And Synthesis

Chemical Properties

Clear light yellow liquid

Uses

Dyeing of acrylic fibers and as a chemical intermediate

Uses

N-Isopropylaniline is a microbial metabolite of Propachlor (P757300), an acylanilide herbicide that is used to maintain crop protection from weeds. Propachlor is also known to induce Glutathione (G597951)-dependent cytotoxicity and sister chromatid exchanges in human cells.

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 3259, 1963 DOI: 10.1021/jo01046a537
Tetrahedron, 52, p. 9777, 1996 DOI: 10.1016/0040-4020(96)00503-0

General Description

N-isopropylaniline is a clear brown liquid. (NTP, 1992)

Air & Water Reactions

Insoluble in water.

Reactivity Profile

N-Isopropylaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Toxic by inhalation and skin absorption.

Health Hazard

N-isopropylaniline absorption causes methemoglobinemia in animals, and the same effect is expected in humans.

Fire Hazard

N-Isopropylaniline is combustible.

N-Isopropylaniline(768-52-5)Related Product Information

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• Lithium diisopropylamide
• N,N-Diisopropylethylamine
• ISOPROPYLHYDRAZINE HYDROCHLORIDE
• Aniline
• POLY(N-ISOPROPYL ACRYLAMIDE)
• N-Isopropylacrylamide
• Chloromethyl isopropyl carbonate
• BRUCINE SULFATE
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• Solvent Black 3
• 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE
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• 1,3,3-Trimethylindolinonaphthospirooxazine
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• 3-ISOPROPYLANILINE, 98+%,3-ISOPROPYLANILINE