5-Bromo-2-methoxy-4-methylpyridine Chemical Properties

Melting point:

33-37 °C(lit.)

Boiling point:

229.6±35.0 °C(Predicted)

Density 

1.45g/ml

Flash point:

225 °F

storage temp. 

0-10°C

pka

1.70±0.18(Predicted)

form 

powder to crystal

color 

White to Almost white

InChIKey

HTBPXLJKMNBQMS-UHFFFAOYSA-N

CAS DataBase Reference

164513-39-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich

5-Bromo-2-methoxy-4-methylpyridine Usage And Synthesis

Synthesis

Sodium acetate (3.54g. 43.23mmol) was added to a solution of 2-methoxy-4-methylpyridine (5.0g.3gmmol) in EtOAc (25mL). Br2 (1 .52mL, 58mmol) was added drop-wise to over 20 mm at 0°C. The RM was stirred at 50°C for 18 h. The total reaction mass was cooled, and after diluting it with water, the pH was adjusted to 8 with aq. NaOH. The organic layer was separated, and aq. Layer extracted with EtOAc (250mL x 3). The combined extract was washed with water (300 mL), brine (200 mL), dried (Na2SO4) and concentrated under reduced pressure to get a crude compound. The crude compound was purified by CC(silica gel 100-200mesh, 0-5 per cent EtOAc in PE) to obtain 5-bromo-2-methoxy-4-methylpyridine (2.82g. 40 per cent) as liquid.

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