4-HYDROXYANTIPYRINE Chemical Properties

Melting point:

184-186 °C (lit.)

Boiling point:

314.3±52.0 °C(Predicted)

Density 

1.294±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

11.99±0.20(Predicted)

color 

Off-White to Beige

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

4-HYDROXYANTIPYRINE Usage And Synthesis

Uses

Antipyrine metabolite

Uses

4-Hydroxyantipyrine is a metabolite of antipyrine (A697500) which is an analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.

Uses

4-Hydroxyantipyrine was used to study the relationships between the metabolism of antipyrine, hexobarbitone and theophylline in man. It was used in a study on flow injection analysis system for the characterisation of pharmaceutical compounds via combination of diode array UV, 1H NMR, FT-IR spectroscopy and time-of-flight mass spectrometry.

Definition

ChEBI: 4-hydroxy-1,5-dimethyl-2-phenyl-3-pyrazolone is a ring assembly and a member of pyrazoles.

General Description

4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine. It is a metabolite of antipyrine.

4-HYDROXYANTIPYRINE(1672-63-5)Related Product Information

• Acethydrazide
• 1，2-Dimethyl hydrazine
• CROTONAMIDE
• N-methyl-N-formylhydrazine
• 1,3-Dimethyl-5-hydroxypyrazole
• N-METHYLACRYLAMIDE
• 2-Hydroxyethylhydrazine
• ETHYLHYDRAZINE
• FORMANILIDE
• TETRAMETHYLHYDRAZINE
• 3H-PYRAZOL-3-ONE, 1,2-DIHYDRO-
• Allylamine
• Phenylhydrazine
• N-PHENYLACRYLAMIDE
• 4-HYDROXYANTIPYRINE
• Acrylamide
• 2-HYDROXYACETAMIDE
• Crotylamine