1,1'-DIOCTADECYL-3,3,3',3'-TETRAMETHYLINDODICARBOCYANINE PERCHLORATE
1,1'-DIOCTADECYL-3,3,3',3'-TETRAMETHYLINDODICARBOCYANINE PERCHLORATE Basic information
- Product Name:
- 1,1'-DIOCTADECYL-3,3,3',3'-TETRAMETHYLINDODICARBOCYANINE PERCHLORATE
- Synonyms:
-
- DiIC18(5) [DiD] [1,1'-Dioctadecyl-3,3,3',3'-tetraMethylindodicarbocyanine perchlorate]
- 3H-INDOLIUM, 2-[5-(1,3-DIHYDRO-3,3-DIMETHYL-1-OCTADECYL-2H-INDOL-2-YLIDENE)-1,3-PENTADIENYL]-3,3-DIMETHYL-1-OCTADECYL-, PERCHLORATE
- DILC18(5)
- DIIC18(5)
- DIIC18(5) OIL
- 'DID' OIL
- DID
- 'DID'
- CAS:
- 127274-91-3
- MF:
- C61H99ClN2O4
- MW:
- 959.9
- Product Categories:
-
- Cyanine
- Mol File:
- 127274-91-3.mol
1,1'-DIOCTADECYL-3,3,3',3'-TETRAMETHYLINDODICARBOCYANINE PERCHLORATE Chemical Properties
- storage temp.
- −20°C
- solubility
- Soluble in ethanol, methanol, dimethyl sulfoxide
- form
- crystals
- color
- Dark brown
- Appearance
- Blue paint solid
- ex/em
- 648/670nm
- ε(extinction coefficient)
- 247000 L⋅mol−1⋅cm−1
- λmax
- 644 nm
- Biological Applications
- Detecting cell lysis,microorganisms,nucleic acids,lipid diffusion in giant unilamellar vesicles,lipid diffusion in phospholipid bilayers,lipids and proteins diffusion in membranes; monitoring cell migration
- InChIKey
- ZQSBJPAQPRVNHU-UHFFFAOYSA-M
- SMILES
- C12C=CC=CC=1C(C)(C)/C(=C\C=C\C=C\C1C(C)(C)C3C=CC=CC=3[N+]=1CCCCCCCCCCCCCCCCCC)/N2CCCCCCCCCCCCCCCCCC.Cl([O-])(=O)(=O)=O
MSDS
- Language:English Provider:SigmaAldrich
1,1'-DIOCTADECYL-3,3,3',3'-TETRAMETHYLINDODICARBOCYANINE PERCHLORATE Usage And Synthesis
Description
DiD is a lipophilic fluorescent probe. It is rapidly incorporated into phospholipid cell membranes and has been used to label the plasma membrane and endocytic organelles in bovine aorta endothelial cells and rat hippocampal slices. DiD has also been used to assess proliferation in prostate cancer cell lines by flow cytometry, where high DiD-expressing cell populations are associated with lower proliferation. DiD is not cytotoxic and can be detected in subcutaneously implanted PC3 cells in vivo after three weeks. It displays absorption/emission maxima of 650/670 nm, respectively.
Chemical Properties
Appearance: Blue lacquer-like solid
ex/em: 648/670nm
Intracellular distribution: Membrane & lipid
Extinction coefficient (ε): 247000 L??mol??1??cm??1
Uses
Fluorescent lipophilic tracer
in vivo
Two weeks after injection of stained cells, a single, bright, DiD perchlorate (DiD)-positive cells located between 15 to 40 μm from the endosteum is found. Results reveal a progressive appearance of cell clusters of decreased dye intensity, consistent with the partitioning of DiD perchlorate label on cell division[3].
storage
Store at -20°C
Excitation / Emission Maximum
549 nm/565 nm
1,1'-DIOCTADECYL-3,3,3',3'-TETRAMETHYLINDODICARBOCYANINE PERCHLORATESupplier
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1,1'-DIOCTADECYL-3,3,3',3'-TETRAMETHYLINDODICARBOCYANINE PERCHLORATE(127274-91-3)Related Product Information
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- 1,1'-DIOCTADECYL-3,3,3',3'-TETRAMETHYLINDODICARBOCYANINE PERCHLORATE ('DID' OIL; DIIC18(5) OIL)
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