Isoindoline Chemical Properties

Melting point:

17 °C (lit.)

Boiling point:

221 °C (lit.)

Density 

1.05 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.57(lit.)

Flash point:

202 °F

storage temp. 

2-8°C

form 

Crystalline Powder, Crystals or Flakes, Darkening On Exposure To Light

pka

9.26±0.20(Predicted)

color 

White to off-white

InChIKey

GWVMLCQWXVFZCN-UHFFFAOYSA-N

CAS DataBase Reference

496-12-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29339980

MSDS

• Language:English Provider:SigmaAldrich

Isoindoline Usage And Synthesis

Description

Isoindoline can be considered as the “hydrogenated sister” of isoindole which is widespread in nature as heterocyclic core of alkaloids and antibiotics.

Uses

Isoindoline is used to make a chiral diamine catalyst from L-proline for the asymmetric acylation of alcohols.1

Uses

Isoindolinone and isoindoline pigments are high quality products. They are used in general and high grade industrial paints including original automobile and automotive refinishes, in plastics and for spin dyeing, and in high grade printing inks, especially for metal deco, laminated plastic sheets, and in printing inks for bank notes and securities.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 5381, 1988 DOI: 10.1021/jo00257a041
Synthetic Communications, 18, p. 2055, 1988 DOI: 10.1080/00397918808068274

Isoindoline(496-12-8)Related Product Information

• Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
• Indole
• 2-Methyl-4-isothiazolin-3-one
• Indoline
• Indometacin
• 3,5-Diisopropylbenzene hydroperoxide
• Dihydromyrcenol
• Indole-3-acetic acid
• Indole-3-butyric acid
• cis-Octahydroisoindole
• 2,3-Dihydroisoindole hydrochloride
• ISOINDOLIN-1-ONE
• ISOINDOLINE-5-CARBONITRILE
• PHTHALIMIDE DBU SALT
• Methyl isonicotinate
• ETHYL ISONICOTINOYLACETATE
• METHYL ISONICOTINATE
• Ethyl isonicotinate