Basic information Safety Supplier Related

C8 CERAMIDE

Basic information Safety Supplier Related

C8 CERAMIDE Basic information

Product Name:
C8 CERAMIDE
Synonyms:
  • N-OCTANOYLSPHINGOSINE, D-ERYTHRO
  • N-OCTANOYL-D-ERYTHRO-SPHINGOSINE
  • N-OCTANOYL-D-SPHINGOSINE
  • N-OCTANOYLSPHINGOSINE
  • D-erythro-N-Octanoylsphingosine
  • N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]Octanamide
  • N-Octanoyl-C18-sphingosine
  • N-Octanoyl-D-erythr
CAS:
74713-59-0
MF:
C26H51NO3
MW:
425.69
Product Categories:
  • Mixed Fatty Acids
  • Activators
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
Mol File:
74713-59-0.mol
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C8 CERAMIDE Chemical Properties

Melting point:
68-70°C
Boiling point:
541.37°C (rough estimate)
Density 
0.9974 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
−20°C
solubility 
DMSO or ethanol: soluble
form 
waxy solid
color 
White
Stability:
Temperature Sensitive
InChIKey
APDLCSPGWPLYEQ-WRBRXSDHSA-N
SMILES
C(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)(=O)CCCCCCC
CAS DataBase Reference
74713-59-0(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29225000

MSDS

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C8 CERAMIDE Usage And Synthesis

Description

C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1?Induces apoptosis.2?Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3?C8-ceramide induces the secretion of brain-derived neurotrophic factor (BDNF) from microglia?in vitro.4

Chemical Properties

Off White Powder

Uses

A biologically active, cell permeable, but nonphysiologic ceramide analog. It induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. It stimulates IL-2 secretion and induces apoptosis

Uses

C-8 Ceramide is a ceramide analog.

Definition

ChEBI: N-octanoylsphingosine is an N-acylsphingosine in which the ceramide N-acyl group is specified as octanoyl. It is functionally related to an octanoic acid.

in vivo

C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8+ and CD4+ T cell responses to viral infections in virus infected mice[3].

Animal Model:C57BL/6 mice, with lymphocytic choriomeningitis virus infected[3]
Dosage:0.1 mg/kg
Administration:Intranasal administration
Result:Increased the CD8+ T cell response to influenza in the lungs.

IC 50

PKC; apoptosis; autophagy

References

[1] S MATHIAS  R N K  K A Dressler. Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1991, 88 22: 10009-10013. DOI:10.1073/pnas.88.22.10009
[2] W D JARVIS. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 1: 73-77. DOI:10.1073/pnas.91.1.73
[3] BRAD L UPHAM . Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis[J]. Cancer letters, 2003, 191 1: Pages 27-34. DOI:10.1016/s0304-3835(02)00620-1
[4] KAZUYUKI NAKAJIMA. Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro[J]. Journal of Neurochemistry, 2002, 80 4: 697-705. DOI:10.1046/j.0022-3042.2001.00752.x

C8 CERAMIDESupplier

Shanghai Renshi Pharmatech Co., LTD Gold
Tel
021-61150625 17721318029
Email
info@renshipharma.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Email
market03@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
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