Basic information Safety Supplier Related

C8 CERAMIDE

Basic information Safety Supplier Related

C8 CERAMIDE Basic information

Product Name:
C8 CERAMIDE
Synonyms:
  • N-OCTANOYLSPHINGOSINE, D-ERYTHRO
  • N-OCTANOYL-D-ERYTHRO-SPHINGOSINE
  • N-OCTANOYL-D-SPHINGOSINE
  • N-OCTANOYLSPHINGOSINE
  • D-erythro-N-Octanoylsphingosine
  • N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]Octanamide
  • N-Octanoyl-C18-sphingosine
  • N-Octanoyl-D-erythr
CAS:
74713-59-0
MF:
C26H51NO3
MW:
425.69
Product Categories:
  • Mixed Fatty Acids
  • Activators
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
Mol File:
74713-59-0.mol
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C8 CERAMIDE Chemical Properties

Melting point:
68-70°C
Boiling point:
541.37°C (rough estimate)
Density 
0.9974 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
−20°C
solubility 
DMSO or ethanol: soluble
form 
waxy solid
color 
White
Stability:
Temperature Sensitive
CAS DataBase Reference
74713-59-0(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29225000

MSDS

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C8 CERAMIDE Usage And Synthesis

Description

C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1?Induces apoptosis.2?Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3?C8-ceramide induces the secretion of brain-derived neurotrophic factor (BDNF) from microglia?in vitro.4

Chemical Properties

Off White Powder

Uses

A biologically active, cell permeable, but nonphysiologic ceramide analog. It induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. It stimulates IL-2 secretion and induces apoptosis

Uses

C-8 Ceramide is a ceramide analog.

Definition

ChEBI: N-octanoylsphingosine is an N-acylsphingosine in which the ceramide N-acyl group is specified as octanoyl. It is functionally related to an octanoic acid.

References

1) Mathias?et al. (1991) Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha; Proc. Natl. Acad. Sci. USA,?88?109 2) Jarvis?et al. (1993)?Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway; Proc. Natl. Acad. Sci. USA?91?73 3) Upham?et al. (2003),?Differential roles of 2,6 and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis; Cancer Lett.,?191?27 4) Nakajima?et al. (2002),?Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro; J. Neurochem.,?80?697

C8 CERAMIDESupplier

Shanghai Renshi Pharmatech Co., LTD Gold
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Shanghai Boyle Chemical Co., Ltd.
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J & K SCIENTIFIC LTD.
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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