Acetrizoic acid Chemical Properties

Melting point:

280-280.5 °C (decomp)

Boiling point:

547.1±50.0 °C(Predicted)

Density 

2.5688 (estimate)

storage temp. 

2-8°C(protect from light)

solubility 

It is soluble in alcohol, slightly soluble in ether and water, very slightly soluble in chloroform and practically insoluble in benzene.

form 

powder to crystal

pka

1.13±0.10(Predicted)

color 

White power

Water Solubility 

1.28g/L(25 ºC)

CAS DataBase Reference

85-36-9(CAS DataBase Reference)

NIST Chemistry Reference

3-Acetamido-2,4,6-triiodobenzoic acid(85-36-9)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

RTECS 

DG0887000

HS Code 

2924.29.7790

Toxicity

LD50 orl-mus: 20 g/kg FRPSAX 18,33,63

Acetrizoic acid Usage And Synthesis

Chemical Properties

Acetrizoic acid is an ionic monomeric contrast medium. It was first synthesized by Wallingford in 1953 and it was filled in the FDA by the Johnson & Johnson subsidiary, Cilag Chemie AG, on February 8th, 1978.Acetrizoic acid presents, in the FDA records, a category of drug substance with an inactive status.

Uses

Radiopaque agent: Acetrizoic acid (trade names Gastrografina, Urografina in Portugal) is a palatable lemon-flavored water-soluble iodinated radiopaque X-ray contrast medium for oral or rectal administration only. Acetrizoic acid is indicated for radiographic examination of segments of the gastrointestinal tract (esophagus, stomach, proximal small intestine, and colon). The preparation is particularly indicated when a more viscous agent such as barium sulfate, which is not water-soluble, is not feasible or is potentially dangerous. Administration of hypertonic Gastrografin solutions may lead to hypovolemia and hypotension due to fluid loss from the intestine.

Definition

ChEBI: Acetrizoic acid is an aminobenzoic acid.

Indications

Acetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid.The X-ray imaging depends on the difference in tissue density which is provided by an X-ray attenuation between the area of interest and the surrounding tissue. The use of contrast agents will provoke a contrast enhancement or opacification and it will improve the differentiation of pathological processes from normal tissue.

brand name

Salpix (Ortho-McNeil).

Safety Profile

Mildly toxic by ingestion andintravenous routes. When heated to decomposition it emitstoxic fumes of I- and NOx.

Acetrizoic acid(85-36-9)Related Product Information

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• Stearic acid
• Folic acid
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• Aceclofenac
• p-Acetylamino benzoic acid
• 4-Aminobenzoic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• (Diacetoxyiodo)benzene
• 1-Bromo-4-iodobenzene
• 4-Iodoanisole
• Ascoric Acid
• Anthranilic acid
• MEGLUMINE DIATRIZOATE
• Diatrizoate sodium
• sodium metrizoate
• IODIPAMIDE