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Rifalazil

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Rifalazil Basic information

Product Name:
Rifalazil
Synonyms:
  • RIFALAZIL
  • KRM 1648
  • 3'-Hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin
  • 1-Deoxy-1'-dehydro-1-oxo-3'-hydroxy-5'-[4-(2-methylpropyl)piperazino]rifamycin VIII
  • 5,12-Dihydroxy-2,4-dimethyl-10-[4-(2-methyl-propyl)-l-piperazinyl]-2,7-[oxy(5-acetoxy-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxo-l,ll,13-pentadecatriene-l,15-diyl)imino]-6H-benzofuro[4,5-a]phenoxazine-l(2H),6-dione
  • Rifalazil USP/EP/BP
CAS:
129791-92-0
MF:
C51H64N4O13
MW:
941.07
Mol File:
129791-92-0.mol
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Rifalazil Chemical Properties

Melting point:
195-200° (dec)
Boiling point:
1065.6±65.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
4°C, away from moisture
solubility 
DMSO: 8.33 mg/mL (8.85 mM)
pka
4.28±0.70(Predicted)
form 
Solid
color 
Blue to dark blue
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Rifalazil Usage And Synthesis

Uses

Antibacterial (antimycobacterial).

Uses

Rifalazil has been used as a part of multi drug regimen in the treatment of tuberculosis.

Definition

ChEBI: Rifalazil is a phenoxazine.

in vivo

Rifalazil (oral gavage; 20, 25, and 150 mg/kg; 6-8 weeks) combines with isoniazid (INH) for 6 weeks or greater significantly reduced the number of mice per group in which M. tuberculosis is detected in both spleens and lungs compared to the reductions for the early and late controls. And the addition of Pyrazinamide (PZA) does not significantly improve RLZ-INH therapy at any time point[2].

Animal Model:Female CD-1 mice infected with 5.2 × 107?viable mycobacteria[2]
Dosage:20, 25, and 150 mg/kg; 6-8 weeks
Administration:Oral gavage
Result:Combined with isoniazid (INH) showed its potential for short-course treatment of?Mycobacterium tuberculosis?infection.

RifalazilSupplier

Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
Email
psaitong@jm-bio.com
TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
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1026@dideu.com
Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
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laboratory@coreychem.com
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 18108052721
Email
2850505130@qq.com
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