Olprinone Chemical Properties

Melting point:

>300°

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO

form 

Powder

pka

6.59±0.10(Predicted)

color 

White to off-white

InChI

InChI=1S/C14H10N4O/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10/h2-6,8H,1H3,(H,17,19)

InChIKey

JPAWFIIYTJQOKW-UHFFFAOYSA-N

SMILES

C1(=O)NC(C)=C(C2=CN3C=CN=C3C=C2)C=C1C#N

CAS DataBase Reference

106730-54-5(CAS DataBase Reference)

Olprinone Usage And Synthesis

Description

Oprinone is an injection developed by Japan Co., Ltd. for the treatment of acute heart failure. It is a specific PDEⅢ inhibitor that selectively blocks cAMP and has high selectivity for the inhibition of human cardiac PDEⅢ.

Uses

Olprinone is used in the treatment of acute myocardial insufficiency.

Definition

ChEBI: Olprinone is a member of bipyridines.

Side effects

1. In the treatment of heart failure, the main adverse reactions of opprinone are manifested in the circulatory system, including premature ventricular contraction, tachycardia, increased ventricular tachyarrhythmia, and increased heart rate. Electric monitoring;
2. As a vasodilator, patients with renal insufficiency should use it in low doses. Long-term oral administration may lead to increased long-term mortality due to large adverse reactions, so it is only used for a short period of time.

Synthesis

4-(Dimethylamino)-3-(pyrimido[1,2-α]pyridin-6-yl)-3-buten-2-one and cyanoacetamide in dimethylformamide at 80~ Heating at 90°C for 12h to obtain Operinone.

References

[1] Patent: CN106349246, 2017, A. Location in patent: Paragraph 0023; 0028; 0029

Olprinone(106730-54-5)Related Product Information

• Tribenuron methyl
• Azamethiphos
• Methyl salicylate
• METSULFURON METHYL
• 2-Chloro-5-chloromethylpyridine
• 4-Methylpyridine
• Methyl acetate
• Pirimiphos-methyl
• 1-Methylimidazole
• 2,6-Lutidine
• Kresoxim-methyl
• 2,4,6-Collidine
• Thiophanate-methyl
• Methyl
• 5,6-DIMETHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE
• Olprinone Hydrochloride
• Methyl bromide
• Parathion-methyl