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Olprinone

Basic information Safety Supplier Related

Olprinone Basic information

Product Name:
Olprinone
Synonyms:
  • 1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile
  • 5-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-3-yl)-6-methyl-2-oxo-1h-pyridine-3-carbonitrile
  • OLPRINONE
  • 5-(Imidazo[1,2-a]pyridine-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
  • Olprinone [inn]
  • 3-phenylmethoxy-1-cyclobutanecarboxylic acid ethyl ester
  • 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile
  • 3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-
CAS:
106730-54-5
MF:
C14H10N4O
MW:
250.26
Product Categories:
  • API
Mol File:
106730-54-5.mol
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Olprinone Chemical Properties

Melting point:
>300°
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO
form 
Powder
pka
6.59±0.10(Predicted)
color 
White to off-white
CAS DataBase Reference
106730-54-5(CAS DataBase Reference)
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Olprinone Usage And Synthesis

Description

Oprinone is an injection developed by Japan Co., Ltd. for the treatment of acute heart failure. It is a specific PDEⅢ inhibitor that selectively blocks cAMP and has high selectivity for the inhibition of human cardiac PDEⅢ.

Uses

Olprinone is used in the treatment of acute myocardial insufficiency.

Definition

ChEBI: Olprinone is a member of bipyridines.

Side effects

1. In the treatment of heart failure, the main adverse reactions of opprinone are manifested in the circulatory system, including premature ventricular contraction, tachycardia, increased ventricular tachyarrhythmia, and increased heart rate. Electric monitoring;
2. As a vasodilator, patients with renal insufficiency should use it in low doses. Long-term oral administration may lead to increased long-term mortality due to large adverse reactions, so it is only used for a short period of time.

Synthesis

4-(Dimethylamino)-3-(pyrimido[1,2-α]pyridin-6-yl)-3-buten-2-one and cyanoacetamide in dimethylformamide at 80~ Heating at 90°C for 12h to obtain Operinone.

Olprinone Preparation Products And Raw materials

Raw materials

OlprinoneSupplier

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