N,N'-Diethylthiourea Chemical Properties

Melting point:

76-78 °C(lit.)

Boiling point:

245°C (estimate)

Density 

1,12 g/cm³

vapor pressure 

0.001Pa at 25℃

refractive index 

1.5300 (estimate)

Flash point:

186 °C

storage temp. 

Store below +30°C.

solubility 

42g/l

form 

solid

pka

14.47±0.70(Predicted)

color 

White to Off-White

PH

7 (38g/l, H2O, 20℃)

Water Solubility 

38 g/L (20 ºC)

BRN 

773905

Stability:

Stable. May be air sensitive. Incompatible with strong oxidizing agents.

InChIKey

FLVIGYVXZHLUHP-UHFFFAOYSA-N

LogP

0.57

CAS DataBase Reference

105-55-5(CAS DataBase Reference)

NIST Chemistry Reference

Diethyl-2-thiourea(105-55-5)

IARC

3 (Vol. 79) 2001

EPA Substance Registry System

N,N'-Diethylthiourea (105-55-5)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-40-45-20/21/22

Safety Statements 

45-36/37-53-24/25

WGK Germany 

2

RTECS 

YS9800000

TSCA 

Yes

HS Code 

29309070

Hazardous Substances Data

105-55-5(Hazardous Substances Data)

MSDS

• Language:English Provider:1,3-Diethyl-2-thiourea
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N,N'-Diethylthiourea Usage And Synthesis

Description

Diethylthiourea, a thiourea derivative, is used mainly as a rubber chemical, particularly in solid neoprene products.

Chemical Properties

white to buff-coloured solid

Uses

Diethyl thiourea is the inhibitor of corrosion in metal pick/ing solutions; accelerator for mercaptan-modified chloroprene rubber; antidegradant for natural, nitrile-butadiene, styrene-butadiene, and chloroprene rubbers

Uses

N,N′-Diethylthiourea can be used as a reactant to prepare:

• 3,5-Diethyltetrahydro-4-thioxo-1,3,5-triazine-1(2H)-propanoic acid by condensation reaction with formaldehyde and β-alanine.
• Methyl 3-ethyl-2-(ethylimino)-3,4-dihydro-4-oxo-2H-1,3-thiazine-6-carboxylate by one-pot reaction with dimethyl acetylenedicarboxylate in the presence of triphenylphosphine catalyst.
• 2-(Ethylimino)-3-ethyl-thiazolidin-4-one by cyclization reaction with 2-chloroacetic acid.
• 3-Ethyl-2-(ethylimino)-4-oxo-5-thiazolidineacetamide by condensation reaction with maleimides via Michael-type reaction.

Definition

ChEBI: Thiourea in which each nitogen carries an ethyl substituent.

General Description

Buff solid or white powder.

Air & Water Reactions

N,N'-Diethylthiourea may be sensitive to exposure to air. . Slightly soluble in water.

Reactivity Profile

N,N'-Diethylthiourea is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition N,N'-Diethylthiourea emits toxic fumes.

Fire Hazard

Flash point data are not available for N,N'-Diethylthiourea, but N,N'-Diethylthiourea is probably combustible.

Flammability and Explosibility

Non flammable

Contact allergens

Diethylthiourea, a thiourea derivative, is used mainly as a rubber chemical, particularly in solid neoprene products.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx

Purification Methods

Crystallise it from *benzene. [Beilstein 4 H 118, 4 I 355, 4 II 610, 4 III 220, 4 IV 375.]

N,N'-Diethylthiourea(105-55-5)Related Product Information

• Mefenpyr-diethyl
• 2-Ethylaniline
• Methoxydiethylborane
• N,N-Diethylhydroxylamine
• Thiourea dioxide
• Ethylene glycol diethyl ether
• Diethyl malonate
• ETHYLTHIOUREA
• Diethyl oxalate
• Triethylenediamine
• N,N'-DIISOPROPYLTHIOUREA
• 1-CYCLOHEXYL-3-(2-MORPHOLINOETHYL)THIOUREA
• 1,3-Dibutyl-2-thiourea
• 1-ALLYL-3-(2-HYDROXYETHYL)-2-THIOUREA
• N,N'-DIALLYLTHIOUREA
• N,N-DI-SEC-BUTYLTHIOUREA
• 1,3-DIETHYL-2-THIOBARBITURIC ACID
• Diethyl ether