Cytidine 5'-monophosphate disodium salt Chemical Properties

Melting point:

300 °C

refractive index 

8 ° (C=2, H2O)

storage temp. 

2-8°C

form 

crystalline

color 

White

InChI

InChI=1/C9H14N3O8P.Na.H/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3

InChIKey

RCIPNLSOCXMZDD-RFFBCSJBNA-N

SMILES

O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.[NaH] |&1:1,2,3,11,r|

CAS DataBase Reference

6757-06-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

22-24/25-37/39-36-26

WGK Germany 

3

F 

1-10

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

Cytidine 5'-monophosphate disodium salt Usage And Synthesis

Uses

Cytidine 5'-Monophosphate Disodium Salt is a salt form of Cytidine 5'-Monophosphate, a constituent of nucleic acids that has been isolated from yeast nucleic acid.

Description

Cytidine 5'-monophosphate disodium salt (5'-CMPNa2) is an organic sodium salt that can be used as a pharmaceutical active ingredient. 5'-CMPNa2 can be used with UMP-Na2, vitamin B6, lipoic acid, and magnesium lactate dihydrate to prepare a capsule-type compound drug for the treatment of polyneuropathy[1].

Chemical Properties

White crystalline powder

Uses

Cytidine 5′-monophosphate disodium salt has been used:

• in nucleotide stock solution
• as an ectonucleotidase (ENTase) inhibitor to probe 5′-ENTase activity in cortical neurons
• in in vitro studies to estimate its effect on growth response of selected bacteria strains that dominate the piglets′ small intestine

Production Methods

The production method of Cytidine 5'-monophosphate disodium salt comprises the following steps: a. adding cytidine, triethyl phosphate and pyridine into a reaction container respectively, and adjusting the reaction temperature to -15-5°C after mixing evenly, and slowly adding a certain amount of phosphorus oxychloride under the temperature condition, and continuing to stir and react for 10-30h after adding; b. taking samples for HPLC analysis, and when the conversion rate is ≥99%, adding 10-15% ice salt water for hydrolysis, and the hydrolysis temperature is controlled to be 0-5°C, and the hydrolysis time is 10-20h; c. after the hydrolysis is completed, standing and stratifying, removing the organic phase, and obtaining a water layer for standby use; d. adjusting the pH of the water layer to 7.0-8.0 with 30% sodium hydroxide, and then dripping 95% alcohol twice the volume of the solution, precipitating crystals, and filtering to obtain a crude product. e. dissolving the crude product, adding activated carbon for decolorization, and continuing to drip 95% alcohol twice the volume of the solution to precipitate crystals, filtering, rinsing, and drying to obtain the finished product Cytidine 5'-monophosphate disodium salt.

Definition

ChEBI: An organic sodium salt that is the disodium salt of CMP.

Biochem/physiol Actions

Cytidine monophosphate?(CMP) serve as a nucleotide?carrier for sugars.

References

[1] M. ALMAKAIEV  L. S  O Bashura. The risk assessment of the combined medicine in the capsule dosage form at the pharmaceutical development stage[J]. News of Pharmacy, 2021. DOI:10.24959/nphj.21.54.

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