2-(Trifluoromethyl)benzyl alcohol Chemical Properties

Melting point:

4°C

Boiling point:

90 °C20 mm Hg(lit.)

Density 

1.326 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.468(lit.)

Flash point:

198 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

pka

14.01±0.10(Predicted)

color 

Colorless to Almost colorless

BRN 

2093714

CAS DataBase Reference

346-06-5(CAS DataBase Reference)

NIST Chemistry Reference

2-(Trifluoromethyl)benzyl alcohol(346-06-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29062990

MSDS

• Language:English Provider:2-(Trifluoromethyl)benzyl alcohol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-(Trifluoromethyl)benzyl alcohol Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

2-(Trifluoromethyl)benzyl alcohol has been used to investigate the aromatic aldehydes as substrate for yeast alcohol dehydrogenase.

Definition

ChEBI: [2-(Trifluoromethyl)phenyl]methanol is a member of (trifluoromethyl)benzenes.

Synthesis

(1) Water (348.0 g) was added to a 1000 mL three-necked round-bottomed flask equipped with a mechanical stirrer and a thermometer and cooled to 0°C. Subsequently, sodium borohydride (9.5 g, 0.25 mol) was added and stirred for 20 min. Maintaining the temperature at 5 °C, o-trifluoromethylbenzaldehyde (87.1 g, 0.5 mol) was slowly added dropwise. After the dropwise addition, the reaction temperature was maintained at 10 °C for 1 hour. After completion of the reaction, extraction was carried out by adding methyl tert-butyl ether. The organic phases were combined, washed with saturated brine and concentrated under reduced pressure to no fraction to obtain 2-trifluoromethylbenzenemethanol as a colorless transparent liquid with a purity of >99% and a yield of 90%.

References

[1] Patent: CN106588673, 2017, A. Location in patent: Paragraph 0047; 0048
[2] Patent: CN106699729, 2017, A. Location in patent: Paragraph 0066; 0067
[3] Green Chemistry, 2015, vol. 17, # 9, p. 4537 - 4540
[4] Journal of Organic Chemistry, 2017, vol. 82, # 13, p. 6972 - 6977

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