Hexamethyldisiloxane Chemical Properties

Melting point:

−59 °C(lit.)

Boiling point:

101 °C(lit.)

Density 

0.764 g/mL at 20 °C(lit.)

vapor density 

>1 (vs air)

vapor pressure 

20 hPa (20 °C)

refractive index 

n20/D 1.377(lit.)

Flash point:

33 °F

storage temp. 

Store below +30°C.

solubility 

0.00037g/l insoluble

form 

liquid

color 

Colorless to Almost colorless

Specific Gravity

0.76

explosive limit

0.5-21.8%(V)

Water Solubility 

insoluble

Hydrolytic Sensitivity

1: no significant reaction with aqueous systems

BRN 

1736258

Dielectric constant

2.2（20℃）

Stability:

Stable, but moisture sensitive. Highly flammable. Incompatible with strong acids, strong bases, oxidizing agents.

InChIKey

UQEAIHBTYFGYIE-UHFFFAOYSA-N

LogP

5.06 at 20℃

CAS DataBase Reference

107-46-0(CAS DataBase Reference)

NIST Chemistry Reference

Disiloxane, hexamethyl-(107-46-0)

EPA Substance Registry System

Hexamethyldisiloxane (107-46-0)

Safety Information

Hazard Codes 

F,N,T

Risk Statements 

11-50/53-65-51/53-48/23/24/25-36/38-46-45

Safety Statements 

16-61-62-45-26-53

RIDADR 

UN 1993 3/PG 2

WGK Germany 

3

RTECS 

JM9237000

F 

10

Autoignition Temperature

340 °C

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29310095

Hazardous Substances Data

107-46-0(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: > 12160 mg/kg LD50 dermal Rat > 2000 mg/kg

MSDS

• Language:English Provider:Hexamethyldisiloxane
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Hexamethyldisiloxane Usage And Synthesis

Chemical Properties

Hexamethyldisiloxane (HMDS) is a colorless or yellowish transparent liquid with a measured melting point of -68.2°C and a measured boiling point of 100.5°C at 1013 hPa. The measured vapor pressure is 44.51 hPa at 20 oC. The measured water solubility is 0.93 ± 0.63 mg/L at 23 oC. The measured log Kow of HMDS is 5.20 at 20 oC. Estimated log Koc values using EPISuite v 4.10 range from 2.5 (MCI method) to 4.5 (Kow method). As Episuite does not contain fragments for siloxanes for log Koc predictions, these values should be treated with caution. The potential for hydrolysis of the test substance may have influenced the determination of partition coefficient and water solubility.

Physical properties

Hexamethyldisiloxane is a colorless and transparent liquid. It is easily deliquescent, flammable, and has the risk of causing combustion when exposed to high heat, open flame, and strong oxidizing agents. Boiling point 99.5℃. Flash point -1.1℃. Relative density (d2525) 0.7606. refractive index 1.3750. insoluble in water, soluble in many organic solvents.

Uses

The most popular precursor chemical is hexamethyldisiloxane (HMDS) which with the addition of helium and oxygen will produce a silica coating. it is used in a variety of consumer applications and can be used as intermediates in the production of silicone polymers.

Uses

Hexamethyldisiloxane is used as a base fluid in a wide range of personal care products that require fast evaporation and high spreadability. When blended with Dimethicone fluids, It can adjust the residence time of the silicone on the skin. Unlike other volatile fluids, Hexamethyldisiloxane Fluid does not cool the skin as it evaporates. Hexamethyldisiloxane is used as a carrying agent and diluent in the following: skin cream lotions, bath oils, suntan lotions, nail polishes, antiperspirants, deodorants, hair sprays and other beauty and hair care products.
A silicon based compound that can be used to create potentially biocompatible materials.
Used as a monomer in the synthesis of long chain polysiloxane structures.
Used in the methylation of mercury(II) salts.

Uses

Hexamethyldisiloxane can be used as silylating agent for carboxylic acids, and alcohols; used in preparation of aroyl chlorides; precursor for a variety of trimethylsilyl derivatives.Hexamethyldisiloxane has been used as an inexpensive starting material for the preparation of numerous synthetically useful trimethylsilyl derivatives.

Preparation

Synthesis of hexamethyldisiloxane by hydrolysis of trimethylsilyl chloride, water and sodium hydroxide.

Definition

ChEBI: Hexamethyldisiloxane is an organosiloxane consisting of two trimethylsilyl groups covalently bound to a central oxygen.

Production Methods

Produced via acid hydrolysis of chlorotrimethylsilane and purification by distillation.

General Description

Hexamethyldisiloxane (HMDSO), a linear polydisiloxane, is an organosilicon reagent commonly utilized as a source for plasma enhanced chemical vapor deposition (PE-CVD) of thin films of silicon compounds. It is also employed as a substitute to silane in silicon integrated circuit technology. Its dissociative ionization by electron impact has been studied by Fourier transform mass spectrometry. Synthesis of plasma-polymerized HMDSO thin films by atmospheric pressure glow (APG) discharge has been reported. Crystals of HMDSO at 148K are monoclinic. Addition of HMDSO to P₄S₁₀, improves its efficiency as thionating agent.

Flammability and Explosibility

Highly flammable

Purification Methods

Fractionally distil through a column packed with glass helices with ca 15 theoretical 20 1.3777. plates. It is highly flammable and is an irritant. [Mills & McKenzie J Am Chem Soc 76 2672 1954, Csakvari et al. J Organometal Chem 107 287 1976, Beilstein 4 IV 4018.]

Hexamethyldisiloxane(107-46-0)Related Product Information

• Chlorodimethylphenylsilane
• POLY(DIMETHYLSILOXANE), HYDROXY TERMINATED
• Dichlorodimethylsilane
• DODECAMETHYLCYCLOHEXASILOXANE
• Hexamethylcyclotrisiloxane
• Hexamethyldisilazane
• Dimethicone
• tert-Butyl methyl ether
• Dimethyldimethoxysilane
• Dimethyl disulfide
• POLYDIMETHYLSILOXANE
• 1,3-Bis(trimethylsilyl)urea
• Octamethylcyclotetrasiloxane
• Lithium bis(trimethylsilyl)amide
• BIS(TRIMETHYLSILYL) SULFIDE
• Hexamethyldisilane
• Heptamethyldisilazane
• Methyltriethoxysilane