MYRISTOLEIC ACID
MYRISTOLEIC ACID Basic information
- Product Name:
- MYRISTOLEIC ACID
- Synonyms:
-
- MYRISTOLEIC ACID
- DELTA 9 CIS TETRADECENOIC ACID
- CIS-9-TETRADECENOIC ACID
- C14:1 (CIS-9) ACID
- 9-tetradecenoic acid
- (Z)-tetradec-9-enoic acid
- MYRISTOLEIC ACID 99%
- 9-Tetradecenoic acid, (9Z)-
- CAS:
- 544-64-9
- MF:
- C14H26O2
- MW:
- 226.35
- EINECS:
- 208-876-8
- Mol File:
- 544-64-9.mol
MYRISTOLEIC ACID Chemical Properties
- Melting point:
- −4.5-−4 °C(lit.)
- Boiling point:
- 144 °C0.6 mm Hg(lit.)
- Density
- 0.9 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.4562(lit.)
- Flash point:
- 62 °C
- storage temp.
- -20°C
- solubility
- Benzene (Slightly), Chloroform (Slightly), Methanol (Slightly)
- form
- Liquid
- pka
- 4.78±0.10(Predicted)
- color
- Colourless
- biological source
- plant
- LogP
- 5.383 (est)
- EPA Substance Registry System
- 9-Tetradecenoic acid, (9Z)- (544-64-9)
MSDS
- Language:English Provider:SigmaAldrich
MYRISTOLEIC ACID Usage And Synthesis
Chemical Properties
Colorless liquid. Found in fatof some seeds and in fish oil.
Uses
Myristoleic Acid induces apoptosis and necrosis in human prostrate cancer cell LNCaP, and is of a potential for developing an attractive new tool for the treatment of prostrate cancer.
Definition
ChEBI: Myristoleic acid is a tetradecenoic acid in which the double bond is at the 9-10 position and has Z configuration. Myristoleic acid has been isolated from Serenoa repens and has cytotoxic and apoptosis-inducing effects. It has a role as an apoptosis inducer, a plant metabolite and an EC 3.1.1.1 (carboxylesterase) inhibitor. It is a tetradecenoic acid and a long-chain fatty acid. It is a conjugate acid of a myristoleate.
in vivo
Myristoleic acid (2 mg/kg, IP every 24 h for 4 days) prevents RANKL-induced bone loss and osteoclast formation in mice[2].
| Animal Model: | C57BL/6 mice at 5 weeks[2]. |
| Dosage: | 0.2, 2 mg/kg |
| Administration: | IP every 24 h for 4 days. |
| Result: | Co-administration of myristoleic acid suppressed generation of TRAP-positive osteoclasts induced by sRANKL and attenuated the increases in osteoclastic indices of Oc.S/BS, N.Oc/B. Pm and ES/BS in a dose-dependent manner. |
IC 50
Human Endogenous Metabolite
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MYRISTOLEIC ACID(544-64-9)Related Product Information
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- Sodium oleate
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- BPMO
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- PALMITOLEIC ACID METHYL ESTER
- DIETHYLENE GLYCOL MONOOLEATE
- Glyceryl Monooleate
- METHYL ABIETATE
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